Pdia2 (protein disulfide isomerase family A, member 2) - Rat Genome Database

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Gene: Pdia2 (protein disulfide isomerase family A, member 2) Rattus norvegicus
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Symbol: Pdia2
Name: protein disulfide isomerase family A, member 2
RGD ID: 1305164
Description: Predicted to enable protein-disulfide reductase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to act upstream of or within platelet aggregation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC287164; Pdip; protein disulfide isomerase A2; protein disulfide isomerase associated 2; protein disulfide isomerase, pancreatic; protein disulfide-isomerase A2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,720,301 - 15,723,386 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,720,301 - 15,723,396 (-)EnsemblGRCr8
mRatBN7.21015,215,824 - 15,218,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,215,824 - 15,220,931 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,955,596 - 19,958,670 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,444,475 - 19,447,549 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,943,755 - 14,946,829 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,376,461 - 15,379,606 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,462,935 - 15,466,009 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,883,630 - 14,886,704 (-)NCBICelera
RGSC_v3.11015,463,985 - 15,467,059 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16677074   PMID:19103594   PMID:19429457   PMID:25122773  


Genomics

Comparative Map Data
Pdia2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,720,301 - 15,723,386 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,720,301 - 15,723,396 (-)EnsemblGRCr8
mRatBN7.21015,215,824 - 15,218,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,215,824 - 15,220,931 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,955,596 - 19,958,670 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,444,475 - 19,447,549 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,943,755 - 14,946,829 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,376,461 - 15,379,606 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,462,935 - 15,466,009 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,883,630 - 14,886,704 (-)NCBICelera
RGSC_v3.11015,463,985 - 15,467,059 (-)NCBI
Cytogenetic Map10q12NCBI
PDIA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816283,164 - 287,215 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16283,152 - 287,215 (+)Ensemblhg38GRCh38
GRCh3716333,164 - 337,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616273,119 - 277,210 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3416273,208 - 277,210NCBI
Celera16533,017 - 537,108 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16251,360 - 255,512 (+)NCBIHuRef
CHM1_116333,055 - 337,171 (+)NCBICHM1_1
T2T-CHM13v2.016278,036 - 282,088 (+)NCBIT2T-CHM13v2.0
Pdia2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,414,973 - 26,418,108 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,414,973 - 26,418,061 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381726,195,999 - 26,199,134 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,195,999 - 26,199,087 (-)Ensemblmm10GRCm38
MGSCv371726,332,944 - 26,336,032 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,923,599 - 25,926,687 (-)NCBIMGSCv36mm8
Celera1726,729,757 - 26,732,844 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.07NCBI
Pdia2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,898,635 - 16,901,799 (-)Ensembl
ChiLan1.0NW_00495544216,898,563 - 16,901,867 (-)NCBIChiLan1.0ChiLan1.0
PDIA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218501,336 - 506,685 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,294,232 - 4,298,939 (+)NCBINHGRI_mPanPan1
PanPan1.116273,692 - 278,014 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16273,764 - 277,914 (+)EnsemblpanPan2panpan1.1
PDIA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,218,566 - 40,221,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,218,550 - 40,231,402 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha641,482,205 - 41,485,425 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0640,560,945 - 40,564,168 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,560,945 - 40,564,149 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,249,209 - 40,252,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,210,283 - 40,213,487 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,688,729 - 40,691,944 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdia2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,536,174 - 112,539,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501634,118 - 637,000 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936501634,034 - 637,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,394,058 - 41,397,687 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1341,394,267 - 41,397,547 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,030,474 - 41,033,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15229,523 - 233,298 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5229,607 - 233,200 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606830,943,512 - 30,947,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdia2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,135,536 - 1,138,819 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249131,135,498 - 1,138,900 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdia2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v193,456,181 - 3,459,282 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdia2
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:87
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000027726
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 16 25 37 92 63 11 24 22 20 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000099303   ⟹   ENSRNOP00000085020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,720,301 - 15,723,396 (-)Ensembl
mRatBN7.2 Ensembl1015,215,824 - 15,220,931 (-)Ensembl
RefSeq Acc Id: NM_001105775   ⟹   NP_001099245
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,720,301 - 15,723,375 (-)NCBI
mRatBN7.21015,215,824 - 15,218,899 (-)NCBI
Rnor_5.01015,376,461 - 15,379,606 (-)NCBI
RGSC_v3.41015,462,935 - 15,466,009 (-)RGD
Celera1014,883,630 - 14,886,704 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085368   ⟹   XP_038941296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,720,301 - 15,723,386 (-)NCBI
mRatBN7.21015,215,826 - 15,218,937 (-)NCBI
RefSeq Acc Id: XM_039085369   ⟹   XP_038941297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,720,301 - 15,723,308 (-)NCBI
mRatBN7.21015,215,826 - 15,218,835 (-)NCBI
RefSeq Acc Id: XR_005489718
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,720,301 - 15,723,386 (-)NCBI
mRatBN7.21015,215,824 - 15,218,937 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099245 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941296 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03998 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085020
  ENSRNOP00000085020.1
RefSeq Acc Id: NP_001099245   ⟸   NM_001105775
- Peptide Label: precursor
- UniProtKB: A0A8I6A0T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038941296   ⟸   XM_039085368
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941297   ⟸   XM_039085369
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000085020   ⟸   ENSRNOT00000099303
Protein Domains
Thioredoxin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305164 AgrOrtholog
BioCyc Gene G2FUF-25724 BioCyc
Ensembl Genes ENSRNOG00000063310 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099303 ENTREZGENE
  ENSRNOT00000099303.2 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Prot_disulphide_isomerase UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report rno:287164 UniProtKB/TrEMBL
NCBI Gene 287164 ENTREZGENE
PANTHER PROTEIN DISULFIDE ISOMERASE UniProtKB/TrEMBL
  PROTEIN DISULFIDE-ISOMERASE A2 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
  Thioredoxin_6 UniProtKB/TrEMBL
PhenoGen Pdia2 PhenoGen
PRINTS THIOREDOXIN UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000063310 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8I6A0T0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-10 Pdia2  protein disulfide isomerase family A, member 2  Pdia2  protein disulfide isomerase associated 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pdia2  protein disulfide isomerase associated 2   Pdia2_predicted  protein disulfide isomerase associated 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Pdia2_predicted  protein disulfide isomerase associated 2 (predicted)  Pdip_predicted  protein disulfide isomerase, pancreatic (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Pdip_predicted  protein disulfide isomerase, pancreatic (predicted)      Symbol and Name status set to approved 70820 APPROVED