Mms22l (MMS22-like, DNA repair protein) - Rat Genome Database

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Pathways
Gene: Mms22l (MMS22-like, DNA repair protein) Rattus norvegicus
Analyze
Symbol: Mms22l
Name: MMS22-like, DNA repair protein
RGD ID: 1304693
Description: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in nucleus. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Orthologous to human MMS22L (MMS22 like, DNA repair protein); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC313108; LOC313108; protein MMS22-like; RGD1304693; similar to CG14803-PA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8542,994,382 - 43,110,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl542,994,359 - 43,110,369 (+)EnsemblGRCr8
mRatBN7.2538,197,707 - 38,313,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl538,197,779 - 38,313,745 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx540,288,528 - 40,404,428 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0541,887,573 - 42,003,473 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0541,820,871 - 41,936,780 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0538,844,502 - 38,960,989 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl538,844,488 - 38,961,035 (+)Ensemblrn6Rnor6.0
Rnor_5.0543,473,579 - 43,590,298 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4539,528,968 - 39,645,371 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera537,133,558 - 37,249,635 (+)NCBICelera
RGSC_v3.1539,529,547 - 39,645,295 (+)NCBI
Cytogenetic Map5q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
FACT complex  (IEA,ISO)
MCM complex  (IEA,ISO)
nuclear replication fork  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
site of DNA damage  (IEA,ISO)
site of double-strand break  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21055983   PMID:21055984   PMID:21055985  


Genomics

Comparative Map Data
Mms22l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8542,994,382 - 43,110,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl542,994,359 - 43,110,369 (+)EnsemblGRCr8
mRatBN7.2538,197,707 - 38,313,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl538,197,779 - 38,313,745 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx540,288,528 - 40,404,428 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0541,887,573 - 42,003,473 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0541,820,871 - 41,936,780 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0538,844,502 - 38,960,989 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl538,844,488 - 38,961,035 (+)Ensemblrn6Rnor6.0
Rnor_5.0543,473,579 - 43,590,298 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4539,528,968 - 39,645,371 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera537,133,558 - 37,249,635 (+)NCBICelera
RGSC_v3.1539,529,547 - 39,645,295 (+)NCBI
Cytogenetic Map5q21NCBI
MMS22L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38697,142,161 - 97,284,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl697,142,161 - 97,283,224 (-)Ensemblhg38GRCh38
GRCh37697,590,037 - 97,731,092 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36697,696,758 - 97,837,773 (-)NCBIBuild 36Build 36hg18NCBI36
Celera698,233,679 - 98,375,346 (-)NCBICelera
Cytogenetic Map6q16.1NCBI
HuRef695,025,862 - 95,167,382 (-)NCBIHuRef
CHM1_1697,852,099 - 97,993,079 (-)NCBICHM1_1
T2T-CHM13v2.0698,315,584 - 98,457,957 (-)NCBIT2T-CHM13v2.0
Mms22l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39424,496,451 - 24,602,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl424,496,451 - 24,602,950 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38424,496,451 - 24,602,950 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl424,496,451 - 24,602,950 (+)Ensemblmm10GRCm38
MGSCv37424,423,609 - 24,530,097 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36424,595,792 - 24,693,579 (+)NCBIMGSCv36mm8
Celera424,232,868 - 24,339,314 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map410.36NCBI
Mms22l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541123,125,121 - 23,245,950 (-)Ensembl
ChiLan1.0NW_00495541123,125,203 - 23,245,941 (-)NCBIChiLan1.0ChiLan1.0
MMS22L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25117,181,663 - 117,332,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16115,059,841 - 115,211,068 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0694,989,906 - 95,127,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1698,873,354 - 99,011,421 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl698,861,299 - 99,011,773 (-)EnsemblpanPan2panpan1.1
MMS22L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11255,584,884 - 55,713,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1255,588,888 - 55,713,341 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1255,404,529 - 55,533,735 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01256,400,771 - 56,530,067 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1256,400,779 - 56,530,011 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11255,737,270 - 55,866,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01255,598,005 - 55,727,110 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01255,845,599 - 55,974,832 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mms22l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494690,119,302 - 90,241,514 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936699486,491 - 608,562 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936699486,510 - 608,532 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMS22L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl164,306,073 - 64,459,904 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1164,306,078 - 64,459,956 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2172,728,444 - 72,948,597 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMS22L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11376,611,574 - 76,750,893 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1376,611,517 - 76,750,616 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604048,920,825 - 49,061,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mms22l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248108,035,864 - 8,168,555 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mms22l
667 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:128
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000009545
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
D5Got219  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2538,307,594 - 38,307,778 (+)MAPPERmRatBN7.2
Rnor_6.0538,954,365 - 38,954,546NCBIRnor6.0
Rnor_5.0543,583,674 - 43,583,855UniSTSRnor5.0
RGSC_v3.4539,638,747 - 39,638,928UniSTSRGSC3.4
Celera537,243,487 - 37,243,668UniSTS
Cytogenetic Map5q21UniSTS
RH137337  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map5177.8UniSTS
Cytogenetic Map5q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 162 91 90 59 92 59 6 353 191 11 141 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009545   ⟹   ENSRNOP00000009545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl542,994,359 - 43,110,369 (+)Ensembl
mRatBN7.2 Ensembl538,197,779 - 38,313,745 (+)Ensembl
Rnor_6.0 Ensembl538,844,488 - 38,961,035 (+)Ensembl
RefSeq Acc Id: NM_001135780   ⟹   NP_001129252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8542,994,414 - 43,110,371 (+)NCBI
mRatBN7.2538,197,779 - 38,313,745 (+)NCBI
Rnor_6.0538,844,546 - 38,960,989 (+)NCBI
Rnor_5.0543,473,579 - 43,590,298 (+)NCBI
RGSC_v3.4539,528,968 - 39,645,371 (+)RGD
Celera537,133,558 - 37,249,635 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109818   ⟹   XP_038965746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8542,994,382 - 43,103,680 (+)NCBI
mRatBN7.2538,197,707 - 38,307,052 (+)NCBI
RefSeq Acc Id: XM_063287584   ⟹   XP_063143654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8542,995,818 - 43,110,371 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001129252 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965746 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143654 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI60888 (Get FASTA)   NCBI Sequence Viewer  
  EDL98534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009545
  ENSRNOP00000009545.5
RefSeq Acc Id: NP_001129252   ⟸   NM_001135780
- UniProtKB: D3ZS39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009545   ⟸   ENSRNOT00000009545
RefSeq Acc Id: XP_038965746   ⟸   XM_039109818
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143654   ⟸   XM_063287584
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS39-F1-model_v2 AlphaFold D3ZS39 1-1240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693601
Promoter ID:EPDNEW_R4126
Type:initiation region
Name:Mms22l_1
Description:MMS22-like, DNA repair protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0538,844,530 - 38,844,590EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304693 AgrOrtholog
BioCyc Gene G2FUF-41793 BioCyc
Ensembl Genes ENSRNOG00000006996 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009545 ENTREZGENE
  ENSRNOT00000009545.8 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7389063 IMAGE-MGC_LOAD
InterPro MMS22-like UniProtKB/TrEMBL
  MMS22L_C UniProtKB/TrEMBL
  MMS22L_N UniProtKB/TrEMBL
KEGG Report rno:313108 UniProtKB/TrEMBL
MGC_CLONE MGC:188308 IMAGE-MGC_LOAD
NCBI Gene 313108 ENTREZGENE
PANTHER PROTEIN MMS22-LIKE UniProtKB/TrEMBL
  PTHR28547 UniProtKB/TrEMBL
Pfam MMS22L_C UniProtKB/TrEMBL
  MMS22L_N UniProtKB/TrEMBL
PhenoGen Mms22l PhenoGen
RatGTEx ENSRNOG00000006996 RatGTEx
UniProt D3ZS39 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Mms22l   MMS22-like, DNA repair protein   RGD1304693  similar to CG14803-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1304693  similar to CG14803-PA   RGD1304693_predicted  similar to CG14803-PA (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1304693_predicted  similar to CG14803-PA (predicted)  LOC313108_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC313108_predicted  similar to CG14803-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL