Brd2 (bromodomain containing 2) - Rat Genome Database

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Gene: Brd2 (bromodomain containing 2) Rattus norvegicus
Analyze
Symbol: Brd2
Name: bromodomain containing 2
RGD ID: 1303324
Description: Predicted to enable acetylation-dependent protein binding activity; histone reader activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromatin looping; nucleosome assembly; and positive regulation of T-helper 17 cell lineage commitment. Predicted to act upstream of or within cell surface receptor signaling pathway via JAK-STAT and neural tube closure. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); PARTICIPATES IN histone modification pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bromodomain-containing 2; bromodomain-containing protein 2; LOC108348112; Ring3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Tcs1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,728,282 - 4,737,286 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,728,951 - 4,737,290 (+)EnsemblGRCr8
mRatBN7.2204,727,078 - 4,735,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,728,151 - 4,735,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,480,415 - 5,487,612 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,842,158 - 4,849,355 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,323,436 - 5,330,635 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,910,555 - 3,921,074 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,262,120 - 5,269,337 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl203,910,555 - 3,917,426 (-)Ensemblrn6Rnor6.0
Rnor_5.0207,323,184 - 7,330,398 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,864,606 - 4,871,813 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,328,831 - 6,336,038 (+)NCBICelera
RGSC_v3.1204,864,832 - 4,872,040 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3'-diindolylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gentamycin  (EXP)
ifosfamide  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methylformamide  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
pyrimidines  (ISO)
quercetin  (ISO)
quinazolines  (ISO)
rac-lactic acid  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IEA,ISO)
chromosome  (IEA)
cytoplasm  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia. Crowley T, etal., Brain Res Dev Brain Res 2004 Apr 19;149(2):93-101.
2. Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Crowley TE, etal., Mol Endocrinol 2002 Aug;16(8):1727-37.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Greenwald RJ, etal., Blood. 2004 Feb 15;103(4):1475-84. Epub 2003 Oct 16.
5. Association of BRD2 polymorphisms with photoparoxysmal response. Lorenz S, etal., Neurosci Lett. 2006 May 29;400(1-2):135-9. Epub 2006 Mar 3.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. Pal DK, etal., Am J Hum Genet 2003 Aug;73(2):261-70. Epub 2003 Jun 25.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The bromodomain: From epigenome reader to druggable target. Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
11. BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Segura MF, etal., Cancer Res. 2013 Oct 15;73(20):6264-76. doi: 10.1158/0008-5472.CAN-13-0122-T. Epub 2013 Aug 15.
12. Brd2 disruption in mice causes severe obesity without Type 2 diabetes. Wang F, etal., Biochem J. 2009 Dec 14;425(1):71-83. doi: 10.1042/BJ20090928.
Additional References at PubMed
PMID:12477932   PMID:15060004   PMID:18406326  


Genomics

Comparative Map Data
Brd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,728,282 - 4,737,286 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,728,951 - 4,737,290 (+)EnsemblGRCr8
mRatBN7.2204,727,078 - 4,735,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,728,151 - 4,735,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,480,415 - 5,487,612 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,842,158 - 4,849,355 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,323,436 - 5,330,635 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,910,555 - 3,921,074 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,262,120 - 5,269,337 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl203,910,555 - 3,917,426 (-)Ensemblrn6Rnor6.0
Rnor_5.0207,323,184 - 7,330,398 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,864,606 - 4,871,813 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,328,831 - 6,336,038 (+)NCBICelera
RGSC_v3.1204,864,832 - 4,872,040 (+)NCBI
Cytogenetic Map20p12NCBI
BRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,968,594 - 32,981,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,968,594 - 32,981,505 (+)Ensemblhg38GRCh38
GRCh37632,936,371 - 32,949,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,044,415 - 33,057,059 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34633,044,414 - 33,057,059NCBI
Celera634,485,349 - 34,498,195 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,678,978 - 32,691,818 (+)NCBIHuRef
CHM1_1632,937,242 - 32,950,091 (+)NCBICHM1_1
T2T-CHM13v2.0632,789,953 - 32,802,871 (+)NCBIT2T-CHM13v2.0
Brd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,330,993 - 34,341,581 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,330,997 - 34,341,608 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381734,112,019 - 34,122,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,112,023 - 34,122,634 (-)Ensemblmm10GRCm38
MGSCv371734,248,964 - 34,258,692 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361733,722,473 - 33,730,354 (-)NCBIMGSCv36mm8
Celera1736,864,043 - 36,873,770 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Brd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,584,479 - 1,592,826 (+)Ensembl
ChiLan1.0NW_0049554371,584,890 - 1,592,486 (+)NCBIChiLan1.0ChiLan1.0
BRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,443,604 - 47,456,467 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,315,229 - 43,328,092 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,538,130 - 32,550,823 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,657,488 - 33,666,054 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,657,648 - 33,666,031 (+)EnsemblpanPan2panpan1.1
BRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,534,034 - 2,546,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,534,034 - 2,546,029 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha122,615,604 - 2,627,599 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0122,864,982 - 2,876,982 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,864,927 - 2,876,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,533,065 - 2,545,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,614,613 - 2,626,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,689,162 - 2,701,159 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Brd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,145,455 - 38,153,085 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,807,163 - 25,818,899 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,807,179 - 25,818,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,150,564 - 25,162,584 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1725,096,579 - 25,162,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,463,191 - 29,529,204 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,113,519 - 39,126,267 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604432,757,658 - 32,770,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,742,509 - 23,750,062 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475423,742,506 - 23,750,668 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Brd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1188,200,198 - 8,208,944 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Brd2
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000000535, ENSRNOT00000060194
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7175096Tcs1T cell selection QTL 1T cell selection trait (VT:0004917)expression2047282825026446Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
AW228947  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0205,990,258 - 5,990,366NCBIRnor5.0
Rnor_5.0207,330,134 - 7,330,242NCBIRnor5.0
Rnor_5.01061,374,939 - 61,375,047NCBIRnor5.0
RGSC_v3.41062,114,541 - 62,114,648UniSTSRGSC3.4
RGSC_v3.4204,871,557 - 4,871,664UniSTSRGSC3.4
Celera206,335,782 - 6,335,889UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map20p12UniSTS
CGCb741  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8204,733,603 - 4,733,777 (+)Marker Load Pipeline
mRatBN7.2204,731,699 - 4,731,873 (-)MAPPERmRatBN7.2
mRatBN7.2204,731,699 - 4,731,873 (+)MAPPERmRatBN7.2
Rnor_6.0205,265,648 - 5,265,821NCBIRnor6.0
Rnor_6.0203,914,071 - 3,914,244NCBIRnor6.0
Rnor_5.0207,326,709 - 7,326,882UniSTSRnor5.0
Rnor_5.0205,993,619 - 5,993,792UniSTSRnor5.0
RGSC_v3.4204,868,131 - 4,868,304UniSTSRGSC3.4
Celera206,332,356 - 6,332,529UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_212495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000535   ⟹   ENSRNOP00000000535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,728,151 - 4,735,382 (+)Ensembl
Rnor_6.0 Ensembl205,262,120 - 5,269,328 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000060194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,732,089 - 4,737,290 (+)Ensembl
mRatBN7.2 Ensembl204,730,185 - 4,735,382 (+)Ensembl
Rnor_6.0 Ensembl203,910,583 - 3,917,224 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,910,555 - 3,917,426 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080585   ⟹   ENSRNOP00000072049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,732,129 - 4,737,290 (+)Ensembl
mRatBN7.2 Ensembl204,728,518 - 4,735,388 (+)Ensembl
Rnor_6.0 Ensembl205,262,466 - 5,269,337 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082900   ⟹   ENSRNOP00000070430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,262,946 - 5,265,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120531   ⟹   ENSRNOP00000098184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,728,951 - 4,737,290 (+)Ensembl
RefSeq Acc Id: NM_212495   ⟹   NP_997660
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,730,079 - 4,737,286 (+)NCBI
mRatBN7.2204,728,175 - 4,735,382 (+)NCBI
Rnor_6.0203,910,562 - 3,917,769 (-)NCBI
Rnor_5.0207,323,184 - 7,330,398 (+)NCBI
RGSC_v3.4204,864,606 - 4,871,813 (+)RGD
Celera206,328,831 - 6,336,038 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772772   ⟹   XP_008770994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,730,880 - 4,737,286 (+)NCBI
mRatBN7.2204,729,003 - 4,735,389 (+)NCBI
Rnor_6.0203,910,555 - 3,916,979 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601578   ⟹   XP_017457067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,728,284 - 4,737,286 (+)NCBI
mRatBN7.2204,727,078 - 4,735,374 (+)NCBI
Rnor_6.0203,910,555 - 3,918,918 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098498   ⟹   XP_038954426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,728,945 - 4,734,852 (+)NCBI
mRatBN7.2204,728,743 - 4,732,948 (+)NCBI
RefSeq Acc Id: XM_063279018   ⟹   XP_063135088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,728,282 - 4,737,286 (+)NCBI
RefSeq Acc Id: XM_063279019   ⟹   XP_063135089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,732,386 - 4,737,286 (+)NCBI
RefSeq Acc Id: NP_997660   ⟸   NM_212495
- UniProtKB: Q6MGA9 (UniProtKB/Swiss-Prot),   A6JJF0 (UniProtKB/TrEMBL),   A0A8I5ZYL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457067   ⟸   XM_017601578
- Peptide Label: isoform X1
- UniProtKB: Q6MGA9 (UniProtKB/Swiss-Prot),   A6JJF0 (UniProtKB/TrEMBL),   A0A8I5ZYL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770994   ⟸   XM_008772772
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZYL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070430   ⟸   ENSRNOT00000082900
Ensembl Acc Id: ENSRNOP00000072049   ⟸   ENSRNOT00000080585
Ensembl Acc Id: ENSRNOP00000000535   ⟸   ENSRNOT00000000535
RefSeq Acc Id: XP_038954426   ⟸   XM_039098498
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063135088   ⟸   XM_063279018
- Peptide Label: isoform X1
- UniProtKB: Q6MGA9 (UniProtKB/Swiss-Prot),   A6JJF0 (UniProtKB/TrEMBL),   A0A8I5ZYL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135089   ⟸   XM_063279019
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K1Z8 (UniProtKB/TrEMBL),   A0A8I5ZYL9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098184   ⟸   ENSRNOT00000120531
Protein Domains
Bromo   NET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MGA9-F1-model_v2 AlphaFold Q6MGA9 1-798 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303324 AgrOrtholog
BioCyc Gene G2FUF-4548 BioCyc
Ensembl Genes ENSRNOG00000000461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000045877 Ensembl
Ensembl Transcript ENSRNOT00000000535.6 UniProtKB/Swiss-Prot
  ENSRNOT00000060194 ENTREZGENE
  ENSRNOT00000080585 ENTREZGENE
  ENSRNOT00000120531 ENTREZGENE
Gene3D-CATH 1.20.1270.220 UniProtKB/Swiss-Prot
  1.20.920.10 UniProtKB/Swiss-Prot
InterPro Bromo_Brdt_I UniProtKB/Swiss-Prot
  Bromo_Brdt_II UniProtKB/Swiss-Prot
  Bromo_chromatin_reader UniProtKB/Swiss-Prot
  Bromodomain UniProtKB/Swiss-Prot
  Bromodomain-like_sf UniProtKB/Swiss-Prot
  Bromodomain_CS UniProtKB/Swiss-Prot
  NET_dom UniProtKB/Swiss-Prot
  NET_sf UniProtKB/Swiss-Prot
KEGG Report rno:294276 UniProtKB/Swiss-Prot
NCBI Gene 294276 ENTREZGENE
PANTHER BROMODOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
  FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS UniProtKB/Swiss-Prot
Pfam BET UniProtKB/Swiss-Prot
  Bromodomain UniProtKB/Swiss-Prot
PhenoGen Brd2 PhenoGen
PRINTS BROMODOMAIN UniProtKB/Swiss-Prot
PROSITE BROMODOMAIN_1 UniProtKB/Swiss-Prot
  BROMODOMAIN_2 UniProtKB/Swiss-Prot
  NET UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000461 RatGTEx
  ENSRNOG00000045877 RatGTEx
SMART BROMO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47370 UniProtKB/Swiss-Prot
UniProt A0A0G2K1Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYL9 ENTREZGENE, UniProtKB/TrEMBL
  A6JJF0 ENTREZGENE, UniProtKB/TrEMBL
  A6JJF1_RAT UniProtKB/TrEMBL
  BRD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Brd2  bromodomain containing 2  LOC108348112  bromodomain-containing protein 2  Data merged from RGD:11509343 737654 PROVISIONAL
2016-08-02 LOC108348112  bromodomain-containing protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Brd2  bromodomain containing 2    bromodomain-containing 2  Name updated 1299863 APPROVED
2005-02-14 Brd2  bromodomain-containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL