Predicted to enable DNA polymerase binding activity. Predicted to be involved in several processes, including interstrand cross-link repair; meiosis I; and mitotic intra-S DNA damage checkpoint signaling. Predicted to act upstream of or within several processes, including neuronal stem cell population maintenance; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be part of DNA repair complex. Predicted to be active in condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast cancer. Orthologous to human FANCD2 (FA complementation group D2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of FANCD2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of FANCD2 mRNA
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of FANCD2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of FANCD2 mRNA
[Arsenic Trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to diepoxybutane and [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to diepoxybutane
[TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of FANCD2 mRNA and TP53 protein affects the reaction [Doxorubicin results in decreased expression of FANCD2 mRNA]
[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea and [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea
Nitrogen Mustard Compounds results in increased expression of FANCD2 mRNA and Nitrogen Mustard Compounds results in increased expression of FANCD2 protein
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] and SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of FANCD2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of FANCD2 mRNA
[Coumestrol co-treated with Resveratrol] results in increased expression of FANCD2 mRNA and [Plant Extracts co-treated with Resveratrol] results in increased expression of FANCD2 mRNA
SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]