GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fancd2 | increases ubiquitination | ISO | FANCD2 (Homo sapiens) | 6480464 | CTD | Mitomycin results in increased ubiquitination of FANCD2 protein | PMID:26208482 | Fancd2 | multiple interactions | ISO | FANCD2 (Homo sapiens) | 6480464 | CTD | [arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin; Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; Mitomycin results in increased expression of and results in increased ubiquitination of FANCD2 protein; Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]] | PMID:24124520 PMID:25092648 | | ||||||||||||||||||||||
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