Ostn (osteocrin) - Rat Genome Database

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Gene: Ostn (osteocrin) Rattus norvegicus
Analyze
Symbol: Ostn
Name: osteocrin
RGD ID: 1303110
Description: Predicted to enable hormone activity. Predicted to be involved in bone growth; hormone-mediated signaling pathway; and negative regulation of dendrite extension. Predicted to act upstream of or within several processes, including cGMP biosynthetic process; negative regulation of D-glucose import; and negative regulation of osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human OSTN (osteocrin); INTERACTS WITH bisphenol A; Muraglitazar; paraquat.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: musclin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,947,023 - 86,983,322 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1186,947,313 - 86,973,427 (-)EnsemblGRCr8
mRatBN7.21173,442,167 - 73,478,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,442,487 - 73,468,603 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1182,285,131 - 82,307,232 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,920,161 - 74,942,266 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,951,063 - 73,973,200 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01176,851,923 - 76,888,140 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,851,322 - 76,888,178 (-)Ensemblrn6Rnor6.0
Rnor_5.01183,841,994 - 83,873,314 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41175,432,572 - 75,455,380 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1172,377,886 - 72,400,027 (-)NCBICelera
RGSC_v3.11175,486,189 - 75,512,971 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Training objectives of a well developed geriatrics program. Pattee JJ J Am Geriatr Soc 1978 Apr;26(4):167-9.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. Thomas G, etal., J Biol Chem 2003 Dec 12;278(50):50563-71. Epub 2003 Oct 01.
Additional References at PubMed
PMID:15044443   PMID:17189616   PMID:17951249   PMID:23940802   PMID:27830782   PMID:33955191  


Genomics

Comparative Map Data
Ostn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,947,023 - 86,983,322 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1186,947,313 - 86,973,427 (-)EnsemblGRCr8
mRatBN7.21173,442,167 - 73,478,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,442,487 - 73,468,603 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1182,285,131 - 82,307,232 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,920,161 - 74,942,266 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,951,063 - 73,973,200 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01176,851,923 - 76,888,140 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,851,322 - 76,888,178 (-)Ensemblrn6Rnor6.0
Rnor_5.01183,841,994 - 83,873,314 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41175,432,572 - 75,455,380 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1172,377,886 - 72,400,027 (-)NCBICelera
RGSC_v3.11175,486,189 - 75,512,971 (-)NCBI
Cytogenetic Map11q22NCBI
OSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383191,199,241 - 191,265,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3191,199,241 - 191,265,615 (+)Ensemblhg38GRCh38
GRCh373190,917,030 - 190,983,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363192,413,016 - 192,450,604 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343192,413,023 - 192,450,612NCBI
Celera3189,359,164 - 189,396,700 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3188,329,884 - 188,367,558 (+)NCBIHuRef
CHM1_13190,893,879 - 190,931,478 (+)NCBICHM1_1
T2T-CHM13v2.03194,014,945 - 194,081,320 (+)NCBIT2T-CHM13v2.0
Ostn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391627,125,733 - 27,169,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1627,126,239 - 27,169,962 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381627,307,641 - 27,351,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1627,307,489 - 27,351,212 (+)Ensemblmm10GRCm38
MGSCv371627,307,727 - 27,351,295 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361627,222,874 - 27,266,442 (+)NCBIMGSCv36mm8
Celera1627,846,676 - 27,890,160 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1618.88NCBI
Ostn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542016,991,576 - 17,035,981 (-)Ensembl
ChiLan1.0NW_00495542016,994,447 - 17,035,576 (-)NCBIChiLan1.0ChiLan1.0
OSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22189,138,390 - 189,207,557 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13189,143,151 - 189,212,269 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03188,491,237 - 188,557,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13196,839,501 - 196,905,696 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3196,852,828 - 196,902,960 (+)EnsemblpanPan2panpan1.1
OSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13423,064,973 - 23,106,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3423,076,910 - 23,104,912 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3427,157,210 - 27,198,723 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03422,999,202 - 23,040,728 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3423,011,258 - 23,041,462 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13423,019,670 - 23,061,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03423,006,318 - 23,047,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03423,248,710 - 23,290,215 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ostn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,934,914 - 120,975,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936900396,821 - 435,911 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936900396,772 - 437,130 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13128,546,915 - 128,574,989 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113128,530,911 - 128,574,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213137,735,950 - 137,970,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11585,372,077 - 85,432,769 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1585,386,221 - 85,416,224 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604159,035,972 - 59,066,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ostn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473066,006,315 - 66,048,434 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473066,009,048 - 66,047,963 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ostn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1412,936,976 - 12,972,636 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000049841
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 17 68 49 48 17 63 17 6 187 113 11 41 40 53 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000049841   ⟹   ENSRNOP00000043654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,947,313 - 86,973,427 (-)Ensembl
mRatBN7.2 Ensembl1173,442,487 - 73,468,603 (-)Ensembl
Rnor_6.0 Ensembl1176,851,322 - 76,888,178 (-)Ensembl
RefSeq Acc Id: NM_207612   ⟹   NP_997495
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,947,023 - 86,983,322 (-)NCBI
mRatBN7.21173,442,197 - 73,478,498 (-)NCBI
Rnor_6.01176,855,895 - 76,878,036 (-)NCBI
Rnor_5.01183,841,994 - 83,873,314 (+)NCBI
RGSC_v3.41175,432,572 - 75,455,380 (-)RGD
Celera1172,377,886 - 72,400,027 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088499   ⟹   XP_038944427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,947,312 - 86,978,149 (-)NCBI
mRatBN7.21173,442,167 - 73,473,326 (-)NCBI
Protein Sequences
Protein RefSeqs NP_997495 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ94967 (Get FASTA)   NCBI Sequence Viewer  
  AAS87600 (Get FASTA)   NCBI Sequence Viewer  
  EDL78125 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043654
  ENSRNOP00000043654.2
GenBank Protein P61365 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997495   ⟸   NM_207612
- Peptide Label: precursor
- UniProtKB: P61365 (UniProtKB/Swiss-Prot),   A6JRY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043654   ⟸   ENSRNOT00000049841
RefSeq Acc Id: XP_038944427   ⟸   XM_039088499
- Peptide Label: isoform X1
- UniProtKB: P61365 (UniProtKB/Swiss-Prot),   A6JRY2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61365-F1-model_v2 AlphaFold P61365 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303110 AgrOrtholog
BioCyc Gene G2FUF-20950 BioCyc
Ensembl Genes ENSRNOG00000030462 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049841 ENTREZGENE
  ENSRNOT00000049841.4 UniProtKB/Swiss-Prot
InterPro Osteocrin UniProtKB/Swiss-Prot
KEGG Report rno:360730 UniProtKB/Swiss-Prot
NCBI Gene 360730 ENTREZGENE
PANTHER OSTEOCRIN UniProtKB/Swiss-Prot
  PTHR35353 UniProtKB/Swiss-Prot
Pfam Musclin UniProtKB/Swiss-Prot
PhenoGen Ostn PhenoGen
RatGTEx ENSRNOG00000030462 RatGTEx
UniProt A6JRY2 ENTREZGENE, UniProtKB/TrEMBL
  OSTN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Ostn  osteocrin      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Ostn  osteocrin      Symbol and Name status set to provisional 70820 PROVISIONAL