Hyal1 (hyaluronidase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Hyal1 (hyaluronidase 1) Rattus norvegicus
Analyze
Symbol: Hyal1
Name: hyaluronidase 1
RGD ID: 1303060
Description: Predicted to enable chondroitin hydrolase activity and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including cellular response to UV-B; cellular response to cytokine stimulus; and regulation of cell growth. Predicted to act upstream of or within embryonic skeletal joint morphogenesis. Predicted to be located in extracellular space; hyaluranon cable; and lysosome. Predicted to be active in cytoplasmic vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to human HYAL1 (hyaluronidase 1); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hyal-1; hyaluronidase-1; hyaluronoglucosaminidase 1; hyaluronoglucosaminidase-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,129,311 - 117,133,162 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,129,277 - 117,133,146 (+)EnsemblGRCr8
mRatBN7.28108,250,668 - 108,254,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,250,667 - 108,260,210 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,877,617 - 113,879,930 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,076,774 - 112,079,087 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,919,556 - 109,921,869 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,332,834 - 116,337,522 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,332,796 - 116,335,435 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,689,184 - 115,691,497 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,824,562 - 112,826,875 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,557,375 - 107,559,688 (+)NCBICelera
RGSC_v3.18112,844,016 - 112,846,330 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
fenamidone  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
Heptachlor epoxide  (ISO)
iron dichloride  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasmic vesicle  (IBA,IEA,ISO,ISS)
extracellular region  (IEA)
extracellular space  (IEA,ISO,ISS)
hyaluranon cable  (IEA,ISO,ISS)
lysosome  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Synthesis and fragmentation of hyaluronan in renal ischaemia. Decleves AE, etal., Nephrol Dial Transplant. 2012 Oct;27(10):3771-81. doi: 10.1093/ndt/gfs098. Epub 2012 Apr 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors. Jacobson A, etal., Int J Cancer 2002 Nov 20;102(3):212-9.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension. Ormiston ML, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L148-57. doi: 10.1152/ajplung.00097.2009. Epub 2009 Nov 13.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. Triggs-Raine B, etal., Proc Natl Acad Sci U S A. 1999 May 25;96(11):6296-300.
Additional References at PubMed
PMID:9223416   PMID:11296287   PMID:11944887   PMID:12084718   PMID:16600643   PMID:16837837   PMID:16900089   PMID:17170110   PMID:17324121   PMID:18390475   PMID:18718911   PMID:18725949  
PMID:18772348   PMID:19478093   PMID:19577615   PMID:20473947   PMID:20554532   PMID:20572808   PMID:21695196   PMID:21699545   PMID:23376485   PMID:23533145   PMID:33904385  


Genomics

Comparative Map Data
Hyal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,129,311 - 117,133,162 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,129,277 - 117,133,146 (+)EnsemblGRCr8
mRatBN7.28108,250,668 - 108,254,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,250,667 - 108,260,210 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,877,617 - 113,879,930 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,076,774 - 112,079,087 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,919,556 - 109,921,869 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,332,834 - 116,337,522 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,332,796 - 116,335,435 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,689,184 - 115,691,497 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,824,562 - 112,826,875 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,557,375 - 107,559,688 (+)NCBICelera
RGSC_v3.18112,844,016 - 112,846,330 (+)NCBI
Cytogenetic Map8q32NCBI
HYAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,299,893 - 50,312,381 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,299,883 - 50,312,890 (-)Ensemblhg38GRCh38
GRCh37350,337,324 - 50,349,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,312,324 - 50,324,816 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34350,312,324 - 50,316,008NCBI
Celera350,310,151 - 50,322,647 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,393,063 - 50,405,514 (-)NCBIHuRef
CHM1_1350,289,626 - 50,302,099 (-)NCBICHM1_1
T2T-CHM13v2.0350,329,249 - 50,342,103 (-)NCBIT2T-CHM13v2.0
Hyal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,454,149 - 107,458,898 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,454,126 - 107,458,909 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389107,576,950 - 107,581,699 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,576,927 - 107,581,710 (+)Ensemblmm10GRCm38
MGSCv379107,479,283 - 107,482,468 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369107,435,053 - 107,438,238 (+)NCBIMGSCv36mm8
Celera9107,185,725 - 107,188,909 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.17NCBI
Hyal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,112,771 - 2,115,952 (-)Ensembl
ChiLan1.0NW_0049555322,113,016 - 2,116,093 (-)NCBIChiLan1.0ChiLan1.0
HYAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,283,105 - 50,297,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,287,719 - 50,303,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,228,491 - 50,238,798 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,463,239 - 51,473,030 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,463,239 - 51,467,286 (-)EnsemblpanPan2panpan1.1
HYAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,035,924 - 39,040,443 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,038,514 - 39,040,368 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2038,955,644 - 38,961,480 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02039,390,640 - 39,396,476 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,385,565 - 39,396,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,758,465 - 38,764,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,162,014 - 39,167,822 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,442,045 - 39,447,881 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hyal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,077,652 - 65,080,619 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,838,676 - 1,841,188 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,838,212 - 1,842,399 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,797,681 - 32,800,793 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11332,798,135 - 32,800,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,976,670 - 35,979,238 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q21NCBI
HYAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,689,123 - 11,693,144 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,688,970 - 11,693,183 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041155,294,855 - 155,298,582 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hyal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,160,557 - 4,165,589 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247304,161,204 - 4,165,554 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hyal1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1898,894,421 - 98,898,265 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hyal1
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:40
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000021408
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 354 191 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021408   ⟹   ENSRNOP00000021408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,129,277 - 117,131,753 (+)Ensembl
mRatBN7.2 Ensembl8108,250,667 - 108,253,110 (+)Ensembl
Rnor_6.0 Ensembl8116,332,796 - 116,335,435 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107744   ⟹   ENSRNOP00000091439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,129,311 - 117,133,146 (+)Ensembl
mRatBN7.2 Ensembl8108,250,667 - 108,260,210 (+)Ensembl
RefSeq Acc Id: NM_001412499   ⟹   NP_001399428
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,129,311 - 117,133,162 (+)NCBI
mRatBN7.28108,250,668 - 108,254,519 (+)NCBI
RefSeq Acc Id: NM_207616   ⟹   NP_997499
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,129,311 - 117,133,162 (+)NCBI
mRatBN7.28108,250,668 - 108,254,519 (+)NCBI
Rnor_6.08116,332,924 - 116,335,237 (+)NCBI
Rnor_5.08115,689,184 - 115,691,497 (+)NCBI
RGSC_v3.48112,824,562 - 112,826,875 (+)RGD
Celera8107,557,375 - 107,559,688 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001399428 (Get FASTA)   NCBI Sequence Viewer  
  NP_997499 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD14368 (Get FASTA)   NCBI Sequence Viewer  
  EDL77243 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091439
GenBank Protein Q76HN1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997499   ⟸   NM_207616
- Peptide Label: isoform 1 precursor
- UniProtKB: Q76HN1 (UniProtKB/Swiss-Prot),   A6I2Y4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021408   ⟸   ENSRNOT00000021408
Ensembl Acc Id: ENSRNOP00000091439   ⟸   ENSRNOT00000107744
RefSeq Acc Id: NP_001399428   ⟸   NM_001412499
- Peptide Label: isoform 2 precursor
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76HN1-F1-model_v2 AlphaFold Q76HN1 1-449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696274
Promoter ID:EPDNEW_R6799
Type:multiple initiation site
Name:Hyal1_1
Description:hyaluronoglucosaminidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,332,795 - 116,332,855EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303060 AgrOrtholog
BioCyc Gene G2FUF-29190 BioCyc
Ensembl Genes ENSRNOG00000015858 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000107744 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  Hyaluronidase UniProtKB/Swiss-Prot
KEGG Report rno:367166 UniProtKB/Swiss-Prot
NCBI Gene 367166 ENTREZGENE
PANTHER HYALURONIDASE-1 UniProtKB/Swiss-Prot
  PTHR11769 UniProtKB/Swiss-Prot
Pfam Glyco_hydro_56 UniProtKB/Swiss-Prot
PhenoGen Hyal1 PhenoGen
PIRSF Hyaluronidase UniProtKB/Swiss-Prot
PRINTS GLHYDRLASE56 UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015858 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
UniProt A0A8I6GJM5_RAT UniProtKB/TrEMBL
  A6I2Y4 ENTREZGENE, UniProtKB/TrEMBL
  F1M963_RAT UniProtKB/TrEMBL
  HYAL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-15 Hyal1  hyaluronidase 1  Hyal1  hyaluronoglucosaminidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hyal1  hyaluronoglucosaminidase 1    hyaluronidase 1  Name updated 1299863 APPROVED
2005-02-14 Hyal1  hyaluronidase 1      Symbol and Name status set to provisional 70820 PROVISIONAL