| 1562602 | Pml | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN PML body organization; apoptotic process (ortholog); branching involved in mammary gland duct morphogenesis (o rtholog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A; 6-propyl-2-thiouracil | 8 | 67523164 | 67557801 | Rat | 484 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564330 | Pram1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetr achlorodibenzodioxine | 7 | 15125813 | 15142494 | Rat | 58 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 621543 | Chek2 | checkpoint kinase 2 | ENCODES a protein that exhibits kinase activity; protein kinase activity; protein serine/threonine kinase activity; INVOLVED IN cellular response to bisphenol A; cellular response to xenobiotic stimulus; DNA damage checkpoint signaling; PARTICIPATES IN p53 signaling pathway; cell cycle pathway, mito tic; ASSOCIATED WITH Kidney Neoplasms; Metabolic Syndrome; urinary bladder cancer; FOUND IN chromosome, telomeric region (ortholog); nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 12 | 51448838 | 51481159 | Rat | 635 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306360 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; cocaine; endosulfan | 12 | 52164214 | 52197860 | Rat | 103 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619813 | Ciita | class II, major histocompatibility complex, transactivator | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to electrical stimulus; cellular response to exogenous dsRNA; cellular response to type II interfe ron; PARTICIPATES IN antigen processing and presentation pathway; influenza A pathway; primary immunodeficiency pathway; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis; periapical periodontitis; acute kidney tubular necrosis (ortholog); FOUND IN cell surface; nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 5646854 | 5694393 | Rat | 202 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560743 | Elf4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN natural killer cell proliferati on (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of interleukin-1 beta production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (ortholog); PML body (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine | X | 132465290 | 132508175 | Rat | 150 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306486 | Habp4 | hyaluronan binding protein 4 | ENCODES a protein that exhibits ribosome binding (ortholog); SUMO binding (ortholog); translation elongation factor binding (ortholog); INVOLVED IN cellular response to mechanical stimulus; PML body organization (ortholog); positive regulation of RNA splicing (o rtholog); FOUND IN cytoplasm; nucleus; sarcomere; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 17 | 940672 | 963358 | Rat | 126 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306145 | Lrch4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (ortholog); positive regulation of toll-like receptor signaling pathway (ortholog); FOUND IN plasma membrane (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; Cuprizon; paracetamol | 12 | 24694364 | 24709354 | Rat | 52 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621101 | Max | MYC associated transcriptional regulator X | ENCODES a protein that exhibits DNA-binding transcription factor activity; identical protein binding; protein-containing complex binding; INVOLVED IN cellular response to peptide hormone stimulus; cellular response to starvation; negative regulation of gene expression; PARTICIPATES IN mitogen activa ted protein kinase signaling pathway; small cell lung carcinoma pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Hereditary Paraganglioma-Pheochromocytoma Syndromes (ortholog); lung small cell carcinoma (ortholog); FOUND IN dendrite; nucleus; PML body; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 6 | 101369989 | 101395333 | Rat | 158 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3200 | Nr2c1 | nuclear receptor subfamily 2, group C, member 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of retinoic acid receptor signaling pathway (ortholog); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 7 | 30602338 | 30655610 | Rat | 134 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3583 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits DNA binding; identical protein binding; nuclear androgen receptor binding; INVOLVED IN cellular response to arsenic-containing substance; cellular response to cytokine stimulus; cellular response to gamma radiation; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN nucleoplasm; nucleus; PML body; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 80625864 | 80647138 | Rat | 198 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308492 | Rpain | RPA interacting protein | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 4 ,4'-sulfonyldiphenol; bisphenol A; bisphenol F | 10 | 56190975 | 56198490 | Rat | 74 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619907 | Serbp1 | Serpine1 mRNA binding protein 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); ribosome binding (ortholog); RNA binding (ortholog); INVOLVED IN regulation of apoptotic process; negative regulation of translation (ortholog); PML body organization (ortholog); ASSOCIATED WITH Dis ease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine | 4 | 97731200 | 97748438 | Rat | 170 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2319689 | Simc1 | SUMO-interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); SUMO polymer binding (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearal anol | 17 | 10066855 | 10112010 | Rat | 54 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620959 | Tdg | thymine-DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding; protein domain specific binding; ATP binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II; base-excision repair (ortholog); epigenetic regulation of gene expression (ortholog); PARTICIPATES IN base excision repair pathway; ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH (+)-pilocarpine; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 22965388 | 22990311 | Rat | 166 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1309320 | Top3a | DNA topoisomerase III alpha | ENCODES a protein that exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN chromosome separation (ortholog); DNA topological change (ortholog); double-strand break repair via homologous recombination (ortholo g); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (ortholog); genetic disease (ortholog); Microcephaly, Growth Restriction, and Increased Sister Chromatid Exchange 2 (ortholog); FOUND IN mitochondrion (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; paracetamol; (S)-colchicine (ortholog) | 10 | 45915625 | 45956856 | Rat | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3889 | Tp53 | tumor protein p53 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; INVOLVED IN apoptotic signaling pathway; cellular response to heat; cellular response to hypoxia; PARTICIPATES IN altered p53 signalin g pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; ASSOCIATED WITH abnormal vacuole morphology; decreased body weight; decreased testis weight; ASSOCIATED WITH bronchiolo-alveolar adenocarcinoma; bronchopulmonary dysplasia; colorectal cancer; FOUND IN chromatin; nucleus; PML body; INTERACTS WITH (+)-catechin; (+)-dexrazoxane; (+)-schisandrin B | 10 | 54798871 | 54810300 | Rat | 4013 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309749 | Trim16 | tripartite motif-containing 16 | ENCODES a protein that exhibits DNA binding (ortholog); interleukin-1 binding (ortholog); NACHT domain binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of keratinocyte d ifferentiation (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); PML body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; aflatoxin B1 | 10 | 47985235 | 48008242 | Rat | 144 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1359439 | Zcchc12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate | X | 120299138 | 120302465 | Rat | 90 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305865 | Zfp451 | zinc finger protein 451 | ENCODES a protein that exhibits SUMO ligase activity (ortholog); transcription corepressor activity (ortholog); transcription regulator inhibitor activity (ortholog); INVOLVED IN negative regulation of transcription initiation by RNA polymerase II (ortholog); negative regulation of transforming grow th factor beta receptor signaling pathway (ortholog); protein sumoylation (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; chloroprene | 9 | 43481395 | 43546103 | Rat | 95 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1593255 | Zmym2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML yle='font-weight:700;'>PML body (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; oxaliplatin | 15 | 35151356 | 35224528 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |