| 620634 | Hr | HR, lysine demethylase and nuclear receptor corepressor | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding; nuclear vitamin D receptor binding; protein-containing complex binding; INVOLVED IN negative regulation of DNA-templated transcription; ASSOCIATED WITH abnormal piliary canal morphology; deformed nails; dilated hair follicle; ASSOCIATED WITH focal segmental glomerulosclerosis; proteinuria; alopecia (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 15 | 52036540 | 52056019 | Rat | 160 | symbol , PANTHER , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 150521603 | Dsg4hr | desmoglein 4; hairless mutant | ASSOCIATED WITH alopecia; ASSOCIATED WITH hypotrichosis | | | | Rat | 2 | symbol | gene, allele |
| 402444115 | Hrurf | HR upstream open reading frame | ASSOCIATED WITH hypotrichosis 4 (ortholog) | 15 | 52036469 | 52039266 | Rat | 2 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 727864 | Hrc | histidine rich calcium binding protein | ENCODES a protein that exhibits ATPase binding (ortholog); calcium ion binding (ortholog); calcium ion sequestering activity (ortholog); INVOLVED IN negative regulation of calcium ion import into sarcoplasmic reticulum; negative regulation of cytosolic calcium ion concentration; calcium ion homeosta sis (ortholog); ASSOCIATED WITH Body Weight (ortholog); Cardiac Fibrosis (ortholog); Cardiomegaly (ortholog); FOUND IN endoplasmic reticulum (ortholog); sarcoplasmic reticulum (ortholog); sarcoplasmic reticulum membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 1 | 104949750 | 104953475 | Rat | 94 | symbol , PANTHER , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 619808 | Hrg | histidine-rich glycoprotein | ENCODES a protein that exhibits heme binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to fungus (ortholog); negative regulation of angiogen esis (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Carotid Atherosclerosis (ortholog); hemorrhagic disease (ortholog); FOUND IN cell surface (ortholog); extracellular region (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,6-dinitrotoluene | 11 | 91559087 | 91573982 | Rat | 207 | symbol , PANTHER , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 70549 | Hrk | harakiri, BCL2 interacting protein | INVOLVED IN cellular response to potassium ion starvation; positive regulation of neuron apoptotic process; positive regulation of apoptotic process (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); FOUND IN mitochondrion (ortholog); I NTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 44048402 | 44070561 | Rat | 167 | symbol , PANTHER , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2827 | Hras | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding; GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN cellular senescence; insulin-like growth factor receptor signaling pathway; liver development; PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ep hrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH abnormal retina apoptosis; ASSOCIATED WITH diabetic retinopathy; Experimental Diabetes Mellitus; Experimental Mammary Neoplasms; FOUND IN plasma membrane; cytosol (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH (S)-nicotine; 1,2-dichlorobenzene; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile | 1 | 205712625 | 205729406 | Rat | 672 | symbol , PANTHER , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 2830 | Hrh1 | histamine receptor H 1 | ENCODES a protein that exhibits histamine binding; histamine receptor activity (ortholog); INVOLVED IN chemical synaptic transmission; negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; PARTICIPATES IN calcium/calcium-mediated signaling pat hway; ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnostic and Therapeutic Materials (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-pyridylethylamine; 6-propyl-2-thiouracil | 4 | 149120511 | 149204267 | Rat | 214 | symbol , PANTHER , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2831 | Hrh2 | histamine receptor H 2 | ENCODES a protein that exhibits heterocyclic compound binding; histamine receptor activity; INVOLVED IN cellular response to histamine; negative regulation of arachidonate secretion; digestive tract development (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; cimetidine pharmacokinet ics pathway; esomeprazole pharmacodynamics pathway; ASSOCIATED WITH transient cerebral ischemia; Chemical and Drug Induced Liver Injury (ortholog); congestive heart failure (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); synapse (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 17 | 10371083 | 10412979 | Rat | 149 | symbol , PANTHER , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 620630 | Hrh3 | histamine receptor H3 | ENCODES a protein that exhibits amine binding; heterocyclic compound binding; INVOLVED IN cAMP metabolic process; cognition; drinking behavior; ASSOCIATED WITH amnestic disorder; Experimental Seizures; gastric ulcer; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH 2-methylpy rrolidine; 3',5'-cyclic AMP; 4,4'-sulfonyldiphenol | 3 | 187569174 | 187575263 | Rat | 160 | symbol , PANTHER , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 620631 | Hrh4 | histamine receptor H4 | ENCODES a protein that exhibits histamine receptor activity; INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); COVID-19 (ortholog); Pruritus (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH 2,4,6-trini trobenzenesulfonic acid; amitrole; ammonium chloride | 18 | 4440977 | 4457132 | Rat | 74 | symbol , PANTHER , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307660 | Hrnr | hornerin | INVOLVED IN cell envelope organization (ortholog); establishment of skin barrier (ortholog); hematopoietic progenitor cell differentiation (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); keratohyalin granule (ortholog); INTERACTS WITH 1,2-dichloroethane (ortholog); 2,3,7,8- tetrachlorodibenzodioxine (ortholog); 2-hydroxypropanoic acid (ortholog) | 2 | 181650772 | 181663633 | Rat | 29 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1305385 | Hrob | homologous recombination factor with OB-fold | ENCODES a protein that exhibits single-stranded DNA binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA synthesis involved in DNA repair (ortholog); female gamete generation (ortholog); ASSOCIATED WITH Ovarian Dysgenesis 11 (ortholog); primary ovarian insufficiency (ortholog); FOUND IN site of DNA damage (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 87705846 | 87722635 | Rat | 79 | symbol , PANTHER , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2323278 | Hrct1 | histidine rich carboxyl terminus 1 | INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; atrazine | 5 | 62778112 | 62778954 | Rat | 40 | symbol , PANTHER , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1594092 | Hrgl1 | histidine-rich glycoprotein like 1 | ENCODES a protein that exhibits heme binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN defense response to fungus (ortholog); negative regulation of angiogenesis (ortholog); negative regulation of blood vessel endothelial cell migration (ort holog); FOUND IN extracellular region (inferred) | 11 | 91543964 | 91553946 | Rat | 50 | symbol , ensembl_gene_symbol , PANTHER , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1583762 | Hrasl1 | HRas proto-oncogene, GTPase like 1 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN signal transduction (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | X | 72587494 | 72588640 | Rat | 14 | symbol , PANTHER , old_gene_name , PhenoGen , name | gene, protein-coding, INFERRED [RefSeq] |
| 127284884 | Aqp4em1Hrt | aquaporin 4; TALEN induced mutant 1, Hrt | ASSOCIATED WITH abnormal glymphatic system physiology; ASSOCIATED WITH Subarachnoid Hemorrhage | | | | Rat | 2 | symbol , name | gene, allele |
| 1310527 | Agfg1-ps1 | ArfGAP with FG repeats 1, pseudogene 1 | INTERACTS WITH rotenone; tetrachloromethane | 3 | 159238347 | 159240363 | Rat | 2 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 70883 | Eif2ak1 | eukaryotic translation initiation factor 2 alpha kinase 1 | ENCODES a protein that exhibits eukaryotic translation initiation factor 2alpha kinase activity; heme binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); HRI-mediated signaling (ortholog); integra ted stress response signaling (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Chemical and Drug Induced Liver Injury (ortholog); hemolytic anemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride | 12 | 15824431 | 15858266 | Rat | 154 | PANTHER , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69225 | Hgs | hepatocyte growth factor-regulated tyrosine kinase substrate | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); ubiquitin-like protein ligase binding (ortholog); INVOLVED IN endosome to lysosome transport; membrane invagination (ortholog); negative regulation of angiogenesis (ortholog); PARTICIPAT ES IN autophagy pathway; vascular endothelial growth factor signaling pathway; endocytosis pathway; FOUND IN secretory granule; cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 106237988 | 106256174 | Rat | 153 | PANTHER , old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 3664 | Srsf5 | serine and arginine rich splicing factor 5 | ENCODES a protein that exhibits protein kinase B binding; RNA binding; RS domain binding (ortholog); INVOLVED IN cellular response to insulin stimulus; liver development; liver regeneration; PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH breast cancer (ortholog); clear cell renal cell carcinom a (ortholog); colon adenocarcinoma (ortholog); FOUND IN nuclear speck (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 6 | 106333998 | 106341467 | Rat | 194 | PANTHER , old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1306590 | Agfg2 | ArfGAP with FG repeats 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); metal ion binding (inferred); zinc ion binding (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 12 | 24649008 | 24692069 | Rat | 101 | PANTHER , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1306183 | Krr1 | KRR1 small subunit processome component | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN ribosomal small subunit biogenesis (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); small-subunit processome (ortholog); INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; bisphenol A | 7 | 49361794 | 49374222 | Rat | 82 | PANTHER , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1562880 | Slc48a1 | solute carrier family 48 member 1 | ENCODES a protein that exhibits heme binding (ortholog); heme transmembrane transporter activity (ortholog); INVOLVED IN heme export (ortholog); heme export from vacuole to cytoplasm (ortholog); heme metabolic process (ortholog); FOUND IN cytoplasm (ortholog); endolysosome (ortholog); endosome membr ane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 7 | 130794233 | 130802119 | Rat | 143 | PANTHER , old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 708345 | Ube2b | ubiquitin-conjugating enzyme E2B | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin protein ligase binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to insulin stimulus; response to hypoxia; ubiquitin-dependent protein catabolic process; PAR TICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); HULC complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 36749365 | 36764335 | Rat | 199 | PANTHER , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1311766 | Cdc73 | cell division cycle 73 | ENCODES a protein that exhibits RNA polymerase II complex binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); endodermal cell fate commitment (ortholog); mRNA 3'-end processing (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II trans cription elongation pathway; ASSOCIATED WITH breast cancer (ortholog); Breast Cancer, Familial (ortholog); colorectal cancer (ortholog); FOUND IN Cdc73/Paf1 complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene | 13 | 57897924 | 58000031 | Rat | 158 | PANTHER , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621013 | Hdgfl2 | HDGF like 2 | ENCODES a protein that exhibits chromatin binding (ortholog); histone H3K27me3 reader activity (ortholog); histone H3K9me2/3 reader activity (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); muscl e cell differentiation (ortholog); positive regulation of cell growth (ortholog); FOUND IN cytoplasm; nucleus; nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 9 | 996687 | 1016352 | Rat | 99 | PANTHER , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628773 | Hdgfl3 | HDGF like 3 | ENCODES a protein that exhibits microtubule binding (ortholog); tubulin binding (ortholog); INVOLVED IN microtubule polymerization (ortholog); negative regulation of microtubule depolymerization (ortholog); neuron projection development (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 1 | 145233996 | 145287115 | Rat | 91 | PANTHER , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309485 | Plaat1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity; A2-type glycerophospholipase activity (ortholog); N-acyltransferase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); lens fiber cell differentiation (ortholog); N-acylphosphatidylethanolamine metabolic process ( ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 11 | 85022297 | 85041999 | Rat | 112 | PANTHER , old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2829 | Plaat3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits A2-type glycerophospholipase activity; phospholipase A1 activity; acyltransferase activity (ortholog); INVOLVED IN negative regulation of cell cycle; ether lipid metabolic process (ortholog); lens fiber cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); lysosome (ortholog); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 214211755 | 214245551 | Rat | 211 | PANTHER , old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1308376 | Plaat5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits N-acyltransferase activity; A2-type glycerophospholipase activity (ortholog); phospholipase A1 activity (ortholog); INVOLVED IN N-acylphosphatidylethanolamine metabolic process; FOUND IN cytosol (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiourac il; acetamide | 1 | 214276553 | 214307600 | Rat | 61 | PANTHER , old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1560070 | Rbfox3 | RNA binding fox-1 homolog 3 | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN regulation of alternative mRNA splicing, via spliceosome (ortholog); ASSOCIATED WITH brain infarction; middle cerebral artery infarction; benign epilepsy with centrotemporal spikes (ortholog); FOUND IN cytoplasm (ortholog); neuronal cell body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-bromopropane; 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran | 10 | 104218940 | 104655863 | Rat | 181 | PANTHER , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 70940 | Rida | reactive intermediate imine deaminase A | ENCODES a protein that exhibits cation binding; identical protein binding; long-chain fatty acid binding; INVOLVED IN G1 to G0 transition; kidney development; lung development; ASSOCIATED WITH Experimental Liver Cirrhosis; Experimental Liver Neoplasms; Acute Liver Failure (ortholog); FOUND IN cytoso l; mitochondrial matrix; peroxisome; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 7 | 67576586 | 67590493 | Rat | 187 | PANTHER , UniProt , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735162 | Ndufaf4 | NADH:ubiquinone oxidoreductase complex assembly factor 4 | ENCODES a protein that exhibits calmodulin binding (inferred); INVOLVED IN negative regulation of apoptotic process; positive regulation of cell population proliferation; defense response to virus (ortholog); ASSOCIATED WITH genetic disease (ortholog); mitochondrial complex I deficiency (ortholog); nuclear type mitochondrial complex I deficiency 1 (ortholog); FOUND IN mitochondrial membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 43401795 | 43406967 | Rat | 113 | PANTHER , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62020 | Prmt1 | protein arginine methyltransferase 1 | ENCODES a protein that exhibits histone methyltransferase activity; identical protein binding; protein methyltransferase activity; INVOLVED IN liver regeneration; peptidyl-arginine methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; PARTICIPATES IN androgen signaling pathw ay; estrogen signaling pathway; histone modification pathway; ASSOCIATED WITH asthma; Diabetic Nephropathies; cleft palate (ortholog); FOUND IN cytosol; protein-containing complex; cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 104595339 | 104605552 | Rat | 318 | PANTHER , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1565519 | Prmt2 | protein arginine methyltransferase 2 | ENCODES a protein that exhibits beta-catenin binding (ortholog); histone H3 methyltransferase activity (ortholog); histone methyltransferase activity (ortholog); INVOLVED IN negative regulation of canonical NF-kappaB signal transduction (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of G1/S transition of mitotic cell cycle (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH asthma; Cocaine-Related Disorders (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene | 20 | 12391388 | 12420096 | Rat | 126 | PANTHER , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620413 | Prmt3 | protein arginine methyltransferase 3 | ENCODES a protein that exhibits modified amino acid binding; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; INVOLVED IN dendritic spine morphogenesis; peptidyl-arginine methylation; peptidyl-arginine methylation, to asymmetrical-dimethy l arginine; PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; homocysteine metabolic pathway; ASSOCIATED WITH asthma; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 108628899 | 108718803 | Rat | 143 | PANTHER , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1309053 | Prmt5 | protein arginine methyltransferase 5 | ENCODES a protein that exhibits protein-containing complex binding; chromatin binding (ortholog); E-box binding (ortholog); INVOLVED IN liver regeneration; negative regulation of cell differentiation; negative regulation of gene expression via chr -weight:700;'>hromosomal CpG island methylation; PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH asthma; Cocaine-Related Disorders (ortholog); diffuse large B-cell lymphoma (ortholog); FOUND IN protein-containing complex; chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 15 | 31938927 | 31948318 | Rat | 211 | PANTHER , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1304701 | Prmt6 | protein arginine methyltransferase 6 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2AR3 methyltransferase activity (ortholog); INVOLVED IN cellular senescence (ortholog); chromatin remodeling (ortholog); nega tive regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH Cocaine-Related Disorders; cocaine dependence (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; amphetamine | 2 | 200615780 | 200620790 | Rat | 152 | PANTHER , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1566295 | Aldh16a1 | aldehyde dehydrogenase 16 family, member A1 | ENCODES a protein that exhibits aldehyde dehydrogenase [NAD(P)+] activity (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (inferred); ASSOCIATED WITH gout (ortholog); HR an>PT-related hyperuricemia (ortholog); hyperuricemia (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 1 | 104763200 | 104776270 | Rat | 73 | PANTHER , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1305964 | Atad3a | ATPase family, AAA domain containing 3A | ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); identical protein binding (ortholog); INVOLVED IN antiviral innate immune response (ortholog); DNA damage response (ortholog); HRI-mediated signaling (ortholog); ASSOCIAT ED WITH cerebellar hypoplasia (ortholog); genetic disease (ortholog); Harel-Yoon syndrome (ortholog); FOUND IN mitochondria-associated endoplasmic reticulum membrane contact site (ortholog); mitochondrial inner membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol | 5 | 171632545 | 171652725 | Rat | 147 | PANTHER , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310343 | Dclre1b | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); beta-lactamase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN interstrand cross-link repair (ortholog); protection from non-homologous end joining at telomere (ortholog); telomere capping (ortholog ); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (ortholog); chromosome, telomeric region (ortholog); nuclear body (ortholog); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium atom | 2 | 193998350 | 194006873 | Rat | 137 | PANTHER , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307845 | Fam8a1 | family with sequence similarity 8, member A1 | FOUND IN Hrd1p ubiquitin ligase complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 17 | 18232834 | 18241736 | Rat | 49 | PANTHER , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1591490 | Kcmf1 | potassium channel modulatory factor 1 | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN HRI-mediated signaling (ortholog); negative regulation of HRI-mediated signaling (ortholog); proteasome-mediated ubiquitin-dependent p rotein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH bisphenol A; endosulfan; flutamide | 4 | 106447974 | 106508359 | Rat | 115 | PANTHER , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3015 | Lox | lysyl oxidase | ENCODES a protein that exhibits copper ion binding; protein-lysine 6-oxidase activity; collagen binding (ortholog); INVOLVED IN cell chemotaxis; collagen fibril organization; elastic fiber assembly; PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm; arteriosclerosis; co ronary artery disease; FOUND IN extracellular matrix; collagen trimer (ortholog); extracellular region (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 18 | 48162889 | 48175640 | Rat | 410 | PANTHER , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 628831 | Nr1h4 | nuclear receptor subfamily 1, group H, member 4 | ENCODES a protein that exhibits bile acid binding; bile acid nuclear receptor activity; chenodeoxycholic acid binding; INVOLVED IN bile acid and bile salt transport; bile acid metabolic process; cellular response to bile acid; PARTICIPATES IN bile acid signaling pathway; bile acid transport pathway; ASSOCIATED WITH liver fibrosis; ASSOCIATED WITH alcoholic hepatitis; Chemical and Drug Induced Liver Injury; cholangiocarcinoma; FOUND IN receptor complex; euchromatin (ortholog); nuclear speck (ortholog); INTERACTS WITH 1,3,7,9-tetramethyluric acid; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 7 | 25733471 | 25829440 | Rat | 911 | PANTHER , old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1359574 | Os9 | OS9, endoplasmic reticulum lectin | ENCODES a protein that exhibits protease binding; glycosylation-dependent protein binding (ortholog); INVOLVED IN protein targeting; ERAD pathway (ortholog); negative regulation of retrograde protein transport, ER to cytosol (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; Endoplasmic R eticulum-associated degradation pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); FOUND IN endoplasmic reticulum lumen; endoplasmic reticulum (ortholog); Hrd1p ubiquitin ligase complex (ortholog); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 7 | 64802517 | 64829185 | Rat | 139 | PANTHER , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1594529 | Rad21 | RAD21 cohesin complex component | ENCODES a protein that exhibits DNA-binding transcription factor binding; lncRNA binding; cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of gene expression; negative regulation of glial cell apoptotic process; negative regulation of interleukin-1 beta production; PARTICIPATES IN cell cycle pathway, mitotic; ASSOCIATED WITH Cerebral Hemorrhage; Spinal Cord Injuries; colorectal carcinoma (ortholog); FOUND IN nucleus; chromatin (ortholog); chromosome, centromeric region (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 7 | 85177715 | 85204657 | Rat | 176 | PANTHER , old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620147 | Sel1l | SEL1L adaptor subunit of SYVN1 ubiquitin ligase | INVOLVED IN ERAD pathway (ortholog); protein secretion (ortholog); response to endoplasmic reticulum stress (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH cerebellar ataxia (ortholog); NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, POOR GROWTH, DYSMORP HIC FACIES, AND AGAMMAGLOBULINEMIA (ortholog); NEURODEVELOPMENTAL DISORDER WITH POOR GROWTH, ABSENT SPEECH, PROGRESSIVE ATAXIA, AND DYSMORPHIC FACIES (ortholog); FOUND IN Derlin-1 retrotranslocation complex (ortholog); endoplasmic reticulum (ortholog); Hrd1p ubiquitin ligase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 6 | 116466163 | 116510436 | Rat | 154 | PANTHER , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310488 | Syvn1 | synoviolin 1 | ENCODES a protein that exhibits DNA-binding transcription factor binding; ATPase binding (ortholog); protein-folding chaperone binding (ortholog); INVOLVED IN ERAD pathway (ortholog); immature B cell differentiation (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN Endoplasmic R eticulum-associated degradation pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH epilepsy (ortholog); FOUND IN Derlin-1 retrotranslocation complex (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum quality control compartment (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 4-phenylbutyric acid; bisphenol A | 1 | 212766736 | 212775426 | Rat | 174 | PANTHER , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1359534 | Ube2a | ubiquitin-conjugating enzyme E2A | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin protein ligase binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN blastocyst hatching (ortholog); chromatin remodeling (ortholog); DNA rep air (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH genetic disease (ortholog); syndromic X-linked intellectual disability Nascimento type (ortholog); FOUND IN chromatin (ortholog); HULC complex (ortholog); XY body (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | X | 120979993 | 120990773 | Rat | 122 | PANTHER , old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305067 | Ube2j1 | ubiquitin-conjugating enzyme E2, J1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN ERAD pathway (ortholog); negative regulation of retrograde protein transport, ER to cytosol (ortholog); protein N-linked glycosylation (ortholog); PARTICIPATES I N Endoplasmic Reticulum-associated degradation pathway; Parkinson's disease pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Hrd1p ubiquitin ligase complex (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; bisphenol A | 5 | 52218807 | 52237805 | Rat | 123 | PANTHER , description | gene, protein-coding, VALIDATED [RefSeq] |