| 620486 | Erbb4 | erb-b2 receptor tyrosine kinase 4 | ENCODES a protein that exhibits neuregulin receptor activity; epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN cellular response to acetylcholine; cellular response to L-glutamate; cellular response to mechanical stimulus; PARTICI PATES IN epidermal growth factor/neuregulin signaling pathway; calcium/calcium-mediated signaling pathway; endocytosis pathway; ASSOCIATED WITH amblyopia; bipolar disorder; congestive heart failure; FOUND IN caveola; dendrite; inhibitory synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol | 9 | 76973386 | 78045633 | Rat | 463 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2299110 | Erbb4Tn(sb-T2/Bart3)2.208Mcwi | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); transposon insertion 2.208, Medical College of Wisconsin | This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Erbb4 gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 1308270 | Acp4 | acid phosphatase 4 | ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN negative regulation of ERBB4 signaling pathway (ortholog); negative regulation of neuron projection development (ortholog); negative regulation of protein processing (ortholog); PARTICIPATES IN riboflavin metabolic pathway; ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1J (ortholog); FOUND IN glutamatergic synapse; postsynaptic membrane; synaptic membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene | 1 | 103872922 | 103888418 | Rat | 55 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310999 | Cadm1 | cell adhesion molecule 1 | ENCODES a protein that exhibits cell adhesion molecule binding; identical protein binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN liver development; negative regulation of ERBB4 signaling pathway; negative regulation of protein phosphorylation; AS SOCIATED WITH hepatocellular carcinoma; lung adenocarcinoma; autistic disorder (ortholog); FOUND IN dendrite; postsynaptic density; axon (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 8 | 56744374 | 57075264 | Rat | 268 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2561 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding; protein tyrosine kinase activity; protein-containing complex binding; INVOLVED IN axon regeneration; cellular response to mechanical stimulus; ERBB2-ERBB4 signaling pathway; PARTICIPATES IN mitogen activated protein kinase signaling pathway; Ras mediated signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH increased metastatic potential; ASSOCIATED WITH amblyopia; congestive heart failure; Diabetic Cardiomyopathies; FOUND IN apical plasma membrane; basal plasma membrane; basolateral plasma membrane; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene | 10 | 83907491 | 83931365 | Rat | 729 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303302 | Nrg2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity; epidermal growth factor receptor binding; ErbB-3 class receptor binding; INVOLVED IN epidermal growth factor receptor signaling pathway; ERBB4 signaling pathway; regulation of synapse ass embly; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrotoluene | 18 | 27890578 | 28072538 | Rat | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1559678 | Nrg3 | neuregulin 3 | ENCODES a protein that exhibits chemorepellent activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN chemorepulsion involved in interneuron migration from the subpallium to the cortex (ortholog); ERBB4 signaling pathway (ortholog); ERBB4 ont-weight:700;'>ERBB4-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); schizophrenia (ortholog); FOUND IN extracellular space (ortholog); glutamatergic synapse (ortholog); synapse (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; glyphosate | 16 | 14256540 | 15374107 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1589860 | Nrg4 | neuregulin 4 | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN ERBB4-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FOUND IN extracellular space (o rtholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; amphetamine | 8 | 64483559 | 64555671 | Rat | 90 | description | gene, protein-coding, VALIDATED [RefSeq] |
