| 2542 | Egf | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; kidney development; positive regulation of DNA biosynthetic process; PAR TICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; ASSOCIATED WITH acute kidney failure; perinatal necrotizing enterocolitis; Wounds and Injuries; FOUND IN extracellular space; extracellular exosome (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1,2-dimethylhydrazine | 2 | 220893660 | 220976331 | Rat | 754 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2526 | Hbegf | heparin-binding EGF-like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity; heparin binding (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; negative regulation of glycoprotein biosynthetic process; positive regulation of cell growth; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; ASSOCIATED WITH acute kidney failure; Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol | 18 | 28380337 | 28390220 | Rat | 413 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563321 | Egfl6 | EGF-like-domain, multiple 6 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN basement membrane (ortholog ); extracellular matrix (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | X | 31515752 | 31573699 | Rat | 91 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 708507 | Egfl7 | EGF-like-domain, multiple 7 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN blood vessel development (ortholog); negative regulation of cell migration (ortholog); negative regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN e xtracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; aflatoxin B1 | 3 | 29802481 | 29814966 | Rat | 119 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1549706 | Egfl8 | EGF-like-domain, multiple 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN in utero embryonic development (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene | 20 | 4137531 | 4140632 | Rat | 41 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 621188 | Megf6 | multiple EGF-like-domains 6 | ENCODES a protein that exhibits calcium ion binding (inferred); scavenger receptor activity (inferred); INVOLVED IN vesicle-mediated transport (inferred); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; ammonium chloride | 5 | 170020699 | 170121557 | Rat | 110 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621190 | Megf8 | multiple EGF-like-domains 8 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter syndrome 2 (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog); INTERACTS WITH amitrole; ammonium chloride; beta-naphthoflavone | 1 | 90030057 | 90079423 | Rat | 145 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1308330 | Megf9 | multiple EGF-like-domains 9 | FOUND IN basement membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 89008679 | 89120731 | Rat | 86 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735084 | Megf10 | multiple EGF-like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 18 | 52803292 | 52953431 | Rat | 144 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1582797 | Megf11 | multiple EGF-like-domains 11 | ENCODES a protein that exhibits scavenger receptor activity (inferred); INVOLVED IN homotypic cell-cell adhesion (ortholog); retina layer formation (ortholog); FOUND IN plasma membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 8 | 73787568 | 74113228 | Rat | 63 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1594185 | Cripto | cripto, EGF-CFC family member | ENCODES a protein that exhibits coreceptor activity (ortholog); growth factor activity (ortholog); nodal binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); anterior/posterior axis specification, embryo (ortholog); cardiac muscle cell differentiation (ortholog); PARTICI PATES IN glypican signaling pathway; ASSOCIATED WITH colon cancer (ortholog); congenital heart disease (ortholog); Forebrain Defects (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH trichloroethene; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog) | 8 | 119803182 | 119808714 | Rat | 121 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1588887 | Edil3 | EGF like and discoidin domains 3 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofura n; amphetamine | 2 | 21625604 | 22140380 | Rat | 86 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1307225 | Egfem1 | EGF-like and EMI domain containing 1 | ENCODES a protein that exhibits calcium ion binding (inferred); FOUND IN extracellular region (inferred); INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; atrazine | 2 | 115601768 | 116253029 | Rat | 8 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1566079 | Sned1 | sushi, nidogen and EGF-like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell-matrix adhesion (inferred); FOUND IN extracellular matrix (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 101221497 | 101281401 | Rat | 89 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1359385 | Dner | delta/notch-like EGF repeat containing | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN central nervous system development (ortholog); glial cell differentiation (ortholog); Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN dendrite (ortholog); early endosome (ortholog); neuronal cell body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 9 | 93035108 | 93350568 | Rat | 158 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1309910 | Vwce | von Willebrand factor C and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cellular response to virus (inferred); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4- dinitrotoluene | 1 | 216703742 | 216753284 | Rat | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1561223 | Vwde | von Willebrand factor D and EGF domains | ENCODES a protein that exhibits calcium ion binding (inferred); ASSOCIATED WITH optic atrophy 12 (ortholog); INTERACTS WITH bisphenol A; indole-3-methanol; 2,3,7,8-tetrachlorodibenzodioxine (ortholog) | 4 | 42419676 | 42468992 | Rat | 39 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 40999476 | Egfl7-ps1 | EGF-like-domain, multiple 7, pseudogene 1 | | 18 | 69590200 | 69593256 | Rat | | symbol , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 1307670 | Ccbe1 | collagen and calcium binding EGF domains 1 | ENCODES a protein that exhibits collagen binding (ortholog); protease binding (ortholog); INVOLVED IN lung development (ortholog); lymph vessel development (ortholog); lymphangiogenesis (ortholog); ASSOCIATED WITH Distal Renal Tubular Acidosis 4 with Hemolytic Anemia (ortholog); Facies (ortholog); g enetic disease (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH bisphenol A; gentamycin; paracetamol | 18 | 61849821 | 62093876 | Rat | 123 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1560078 | Celsr1 | cadherin, EGF LAG seven-pass G-type receptor 1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); establishment of body hair pl anar orientation (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); long QT syndrome (ortholog); Lymphatic Malformation 9 (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 7 | 118867450 | 119004859 | Rat | 169 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 69237 | Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN dendrite morphogenesis; regulation of cell-cell adhesion; spermatogenesis; ASSOCIATED WITH coronary artery disease (orthol og); Developmental Disabilities (ortholog); endometrial hyperplasia (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; aflatoxin B1 | 2 | 198717333 | 198741689 | Rat | 148 | old_gene_name , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621787 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN axonal fasciculation (ortholog); cilium assembly (ortholog); dopaminergic neuron axon guidance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); CAKUT1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic active zone membrane (ortholog); INTERACTS WITH ammonium chloride; atrazine; bis(2-ethylhexyl) phthalate | 8 | 118409136 | 118438593 | Rat | 128 | old_gene_name , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308528 | Efemp1 | EGF-like fibulin extracellular matrix protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN negative regulation of neuron projection development; positive regulation of cell population proliferation; positive regulation of cell projection or ganization; ASSOCIATED WITH adenocarcinoma (ortholog); adenoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane; extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 106811769 | 106890961 | Rat | 253 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1359496 | Efemp2 | EGF-like fibulin extracellular matrix protein 2 | ENCODES a protein that exhibits heparin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aorta development (ortholog); aorta smooth muscle tissue morphogenesis (ortholog); artery development (ortholog); ASSOCIATED WITH osteoarthritis; aortic aneurysm (ortholog); aortic d isease (ortholog); FOUND IN basement membrane (ortholog); elastic fiber (ortholog); extracellular matrix (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide | 1 | 212211057 | 212218739 | Rat | 159 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1564641 | Heg1 | heart development protein with EGF-like domains 1 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cardiac atrium morphogenesis (ortholog); cardiac muscle tissue growth (ortholog); cell-cell junction organization (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrolein; amphetamine | 11 | 80512096 | 80600150 | Rat | 147 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306592 | Egflam | EGF-like, fibronectin type III and laminin G domains | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); synapse assembly (ortholog); ASSOCIATED WITH High Myopia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular matrix (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; amitrole | 2 | 58029934 | 58204010 | Rat | 112 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3083 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylethanolamine binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN positive regulation of cell population proliferation; response to estrogen; apoptotic cell clearance (ortholog); ASSOCIATED WITH Breast Neoplas ms (ortholog); colorectal cancer (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol | 1 | 142474027 | 142489431 | Rat | 183 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1309015 | Scube1 | signal peptide, CUB domain and EGF like domain containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN positive regulation of smoothened signaling pathway (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; atraz ine; bisphenol A | 7 | 116639027 | 116760986 | Rat | 82 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563998 | Scube2 | signal peptide, CUB domain and EGF like domain containing 2 | ENCODES a protein that exhibits hedgehog family protein binding (ortholog); INVOLVED IN chondrocyte differentiation involved in endochondral bone morphogenesis (ortholog); positive regulation of chondrocyte proliferation (ortholog); positive regulation of ossification (ortholog); FOUND IN extracellu lar space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dimethylarsinic acid; endosulfan | 1 | 173264862 | 173341323 | Rat | 92 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1304880 | Scube3 | signal peptide, CUB domain and EGF like domain containing 3 | ENCODES a protein that exhibits BMP binding (ortholog); BMP receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of BMP signaling pathway (ortholog); positive regulation of osteoblast differentiation (ortholog); positive regulation of smoothened signalin g pathway (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,7-dihydropurine-6-thione | 20 | 6200891 | 6232848 | Rat | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1359357 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | ENCODES a protein that exhibits protein O-acetylglucosaminyltransferase activity (ortholog); INVOLVED IN protein O-linked glycosylation (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 4 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum lu men (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 4 | 131275587 | 131313243 | Rat | 91 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621642 | Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN vasculogenesis; aortic valve morphogenesis (ortholog); blood vessel development (ortholog); ASSOCIATED WITH Lymphatic Malformation 11 (ortholog); FOUND IN plasma membrane (o rtholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; atrazine | 5 | 137285408 | 137305047 | Rat | 124 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62005 | Tmeff1 | transmembrane protein with EGF-like and two follistatin-like domains 1 | ENCODES a protein that exhibits receptor ligand inhibitor activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzof uran | 5 | 67706269 | 67792022 | Rat | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308839 | Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of integrin biosynthetic process (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic ovary syndrome (ortholog); prostate cancer (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole | 9 | 57937873 | 58225372 | Rat | 124 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1588987 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | ENCODES a protein that exhibits chromatin binding (ortholog); integrin binding (ortholog); integrin binding involved in cell-matrix adhesion (ortholog); INVOLVED IN epidermis development (ortholog); gene expression (ortholog); lymph circulation (ortholog); FOUND IN cytoplasm (ortholog); extracellula r region (ortholog); extracellular space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 5 | 77606523 | 77783292 | Rat | 146 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1309143 | Dlk2 | delta like non-canonical Notch ligand 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); regulation of fat cell differentiation (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil | 9 | 22174667 | 22179149 | Rat | 77 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1359214 | Adgre1 | adhesion G protein-coupled receptor E1 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell periphery (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 9 | 2329398 | 2484959 | Rat | 197 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62009 | Zfp36l1 | zinc finger protein 36, C3H type-like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding; mRNA binding; 14-3-3 protein binding (ortholog); INVOLVED IN mRNA catabolic process; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay; positive regulation of nuclear-transcribed mRNA catabolic process, dea denylation-dependent decay; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytosol; cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 6 | 104663396 | 104669815 | Rat | 311 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621136 | Adgrl4 | adhesion G protein-coupled receptor L4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN protein-containing complex assembly; ASSOCIATED WITH glioblastoma; hypertrophic cardiomyopathy (ortholog); Left Ventricula r Hypertrophy (ortholog); FOUND IN cytoplasmic vesicle; plasma membrane; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 243014927 | 243117226 | Rat | 100 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620656 | Fat2 | FAT atypical cadherin 2 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN homophilic cell-cell adhesion; cell-substrate adhesion (ortholog); epithelial cell migration (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); spastic ataxia (ortholog); spinocerebellar ataxia 45 (ort holog); FOUND IN adherens junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; alpha-Zearalanol | 10 | 39864765 | 39957027 | Rat | 99 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69307 | Slit1 | slit guidance ligand 1 | ENCODES a protein that exhibits heparan sulfate proteoglycan binding; Roundabout binding (ortholog); INVOLVED IN negative regulation of axon extension involved in axon guidance; spinal cord development; axon extension involved in axon guidance (ortholog); ASSOCIATED WITH Brain Injuries; Monomelic Am yotrophy (ortholog); Spinal Cord Injuries (ortholog); FOUND IN extracellular space; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 1 | 250358917 | 250507476 | Rat | 150 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 69311 | Slit3 | slit guidance ligand 3 | ENCODES a protein that exhibits Roundabout binding (ortholog); INVOLVED IN spinal cord development; animal organ morphogenesis (ortholog); aortic valve morphogenesis (ortholog); ASSOCIATED WITH Brain Injuries; congenital diaphragmatic hernia; atrial fibrillation (ortholog); FOUND IN cell junction (o rtholog); extracellular space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 20075929 | 20660704 | Rat | 193 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309412 | Creld1 | CRELD disulfide isomerase 1 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Congenital Heart Defects, Multiple Types, 4 (ortholog); congenital heart disease (ortholog); FO UND IN glutamatergic synapse (ortholog); synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 4 | 148187510 | 148197120 | Rat | 95 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310614 | Creld2 | CRELD disulfide isomerase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); isomerase activity (inferred); protein disulfide isomerase activity (inferred); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2 ,3,7,8-tetrachlorodibenzodioxine | 7 | 121788754 | 121796230 | Rat | 152 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2594 | Fbln5 | fibulin 5 | ENCODES a protein that exhibits integrin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN regulation of cell growth; elastic fiber assembly (ortholog); extracellular matrix organization (ortholog); ASSOCIATED WITH adult respiratory distress syndrome (ortholog); age relat ed macular degeneration (ortholog); age related macular degeneration 1 (ortholog); FOUND IN extracellular space; elastic fiber (ortholog); extracellular matrix (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl | 6 | 126664100 | 126742847 | Rat | 220 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 7747752 | Cdhr17 | cadherin related family member 17 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN cell adhesion (inferred); homophilic cell-cell adhesion (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | 4 | 19382943 | 19480347 | Rat | 7 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 2431 | Cspg5 | chondroitin sulfate proteoglycan 5 | INVOLVED IN axon regeneration; cytoskeleton organization; glial cell projection elongation; FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 8 | 119098932 | 119113191 | Rat | 101 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1359641 | Adgre4 | adhesion G protein-coupled receptor E4 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); signal transd uction (inferred); FOUND IN cell surface (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 10085258 | 10240346 | Rat | 76 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 628822 | Stab2 | stabilin 2 | ENCODES a protein that exhibits hyaluronic acid binding; cargo receptor activity (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN endocytosis; defense response to bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN external side of plasma membrane; cytosol (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol | 7 | 23136938 | 23342633 | Rat | 103 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2543 | Egfr | epidermal growth factor receptor | ENCODES a protein that exhibits calmodulin binding; epidermal growth factor binding; epidermal growth factor receptor activity; INVOLVED IN astrocyte activation; cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; PARTICIPATES IN epidermal growth facto r/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; ASSOCIATED WITH abnormal estrous cycle; heart left ventricle hypertrophy; renal fibrosis; ASSOCIATED WITH acute kidney failure; asthma; bronchiolo-alveolar adenocarcinoma; FOUND IN apical plasma membrane; basolateral plasma membrane; cell surface; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine | 14 | 95378626 | 95551358 | Rat | 1456 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 152999024 | Aif1tm(EGFP)Apps | allograft inflammatory factor 1; target mutant 1,Apps | Applied StemCell, Inc (Milpitas, CA) was contracted to generate the Iba1-EGFP knock-in rat model using CRISPR/Cas9 technology in the Sprague Dawley rat strain. The donor construct inserted consisted of the EGFP coding sequen ce (minus the first ATG), followed by the 22 amino acid sequence of the porcine teschovirus-1 2A (P2A) self-cleaving peptide, and then the first exon of the rat Iba1 gene immediately downstream of the translational start site. Guide RNA with the following sequence: 5'- TACCCTGCAAATCCTTGCTCTGG-3' targeting the Iba1 gene just downstream of the translational start site were used. | | | | Rat | | symbol , description | gene, allele |
| 126781692 | Csf1rtm(EGFP)Tset | colony stimulating factor 1 receptor; target mutant, Tset | ASSOCIATED WITH abnormal brain development; abnormal corpus callosum size; absent teeth; ASSOCIATED WITH bone development disease; infertility; lymphopenia | | | | Rat | 27 | symbol | gene, allele |
| 12792957 | Tp53tm1(EGFP-Pac)Qly | tumor protein p53; tm1, EGFP-Pac, Qly | This allele was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.7kb 5' and 1.6- kb 3' homology arms and a CAG-EGFP-IRES-Pac cassette. Absence of Tp53 protein was confirmed by western blot in homozygous animals. | | | | Rat | | symbol , name , description , old_gene_symbol | gene, allele |
| 620998 | Nell1 | neural EGFL like 1 | ENCODES a protein that exhibits heparin binding; identical protein binding; protein kinase C binding; INVOLVED IN positive regulation of apoptotic process; positive regulation of ossification; regulation of osteoblast differentiation; ASSOCIATED WITH abnormal craniofacial bone morphology; ASSOCIATED WITH craniosynostosis; esophagus adenocarcinoma (ortholog); prostate cancer (ortholog); FOUND IN extracellular space; cytoplasm (ortholog); nuclear envelope (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 108845462 | 109709858 | Rat | 125 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 620999 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding; identical protein binding; protein kinase C binding; INVOLVED IN development of secondary female sexual characteristics; neurogenesis; neuron cellular homeostasis; ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm; dendrite; extracell ular space; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 128222333 | 128542127 | Rat | 142 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1310590 | Eps8 | EGFR pathway substrate 8, signaling adaptor | ENCODES a protein that exhibits actin binding (ortholog); small GTPase binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCI ATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 102 (ortholog); autosomal recessive nonsyndromic deafness 106 (ortholog); FOUND IN glutamatergic synapse; postsynaptic density; brush border (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 4 | 172119497 | 172291670 | Rat | 232 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306494 | Vopp1 | VOPP1 WW domain binding protein | ENCODES a protein that exhibits enzyme binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN DNA-templated transcription (inferred); ASSOCIATED WITH acute myeloid leukemia (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); endos ome (ortholog); late endosome (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane | 4 | 88692784 | 88762903 | Rat | 95 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625813034 | Fmr1em1Sidb | FMRP translational regulator 1; ZFN induced mutant1,Sidb | ASSOCIATED WITH abnormal afterhyperpolarization; abnormal brain wave pattern; abnormal habituation to a new environment; ASSOCIATED WITH fragile X syndrome | | | | Rat | 10 | description | gene, allele |
| 620446 | Shc1 | SHC adaptor protein 1 | ENCODES a protein that exhibits epidermal growth factor receptor binding; phosphoprotein binding; phosphotyrosine residue binding; INVOLVED IN actin cytoskeleton organization; animal organ regeneration; cellular response to hydrogen peroxide; PARTICIPATES IN mitogen activated protein kinase signalin g pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH decreased tubuloglomerular feedback response; decreased urine albumin level; glomerulosclerosis; ASSOCIATED WITH Albuminuria; Chronic Hepatitis; familial hyperlipidemia; FOUND IN endosome membrane; Shc-EGFR complex; cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 17beta-estradiol | 2 | 177135649 | 177147257 | Rat | 363 | description | gene, protein-coding, VALIDATED [RefSeq] |