Adgre4 (adhesion G protein-coupled receptor E4) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Adgre4 (adhesion G protein-coupled receptor E4) Rattus norvegicus
Analyze
Symbol: Adgre4
Name: adhesion G protein-coupled receptor E4
RGD ID: 1359641
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human ADGRE4P (adhesion G protein-coupled receptor E4, pseudogene); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adgre4p; EGF-like module containing, mucin-like, hormone receptor-like 4; EGF-like module containing, mucin-like, hormone receptor-like sequence 4; EGF-like module-containing mucin-like hormone receptor-like 4; Emr4; Emr4p
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8910,085,258 - 10,240,346 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl910,085,352 - 10,240,229 (+)EnsemblGRCr8
mRatBN7.299,758,106 - 9,901,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl99,760,355 - 9,900,760 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx912,789,876 - 12,922,137 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0917,028,384 - 17,160,643 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0915,790,355 - 15,922,622 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd912,811,991 - 12,955,310 (+)NCBI
Lyon_Normotensive912,047,561 - 12,190,896 (+)NCBI
Lyon_Hypertensive912,488,473 - 12,631,803 (+)NCBI
F344_StmMcwi97,082,360 - 7,216,387 (-)NCBI
Rnor_6.098,056,034 - 8,200,262 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl98,052,210 - 8,198,800 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.097,096,164 - 7,239,092 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera95,534,515 - 5,670,994 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12023293   PMID:15578266  


Genomics

Comparative Map Data
Adgre4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8910,085,258 - 10,240,346 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl910,085,352 - 10,240,229 (+)EnsemblGRCr8
mRatBN7.299,758,106 - 9,901,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl99,760,355 - 9,900,760 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx912,789,876 - 12,922,137 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0917,028,384 - 17,160,643 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0915,790,355 - 15,922,622 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd912,811,991 - 12,955,310 (+)NCBI
Lyon_Normotensive912,047,561 - 12,190,896 (+)NCBI
Lyon_Hypertensive912,488,473 - 12,631,803 (+)NCBI
F344_StmMcwi97,082,360 - 7,216,387 (-)NCBI
Rnor_6.098,056,034 - 8,200,262 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl98,052,210 - 8,198,800 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.097,096,164 - 7,239,092 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera95,534,515 - 5,670,994 (+)NCBICelera
Cytogenetic Map9q12NCBI
ADGRE4P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,950,758 - 6,997,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,954,659 - 6,990,798 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37196,950,769 - 6,997,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,903,511 - 6,941,857 (-)NCBIBuild 36Build 36hg18NCBI36
Celera196,893,527 - 6,932,800 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef196,715,080 - 6,753,367 (-)NCBIHuRef
CHM1_1196,952,322 - 6,990,906 (-)NCBICHM1_1
T2T-CHM13v2.0196,940,057 - 6,988,111 (-)NCBIT2T-CHM13v2.0
Adgre4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,056,984 - 56,160,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,056,984 - 56,175,274 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381755,749,984 - 55,853,662 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1755,749,984 - 55,853,662 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371755,889,249 - 55,992,927 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361755,343,122 - 55,446,606 (+)NCBIMGSCv36mm8
Celera1759,168,585 - 59,272,252 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1728.98NCBI
EMR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,342,233 - 53,385,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,342,420 - 53,377,610 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,091,017 - 53,128,023 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02053,993,706 - 54,037,282 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,820,811 - 54,029,551 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,063,265 - 53,098,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,510,867 - 53,546,060 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,741,897 - 53,777,089 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100522787
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1272,071,804 - 72,113,035 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,440,469 - 72,479,902 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Adgre4
3326 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:87
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000073659
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
266 151 622 1389 3177 988 1706 98 851 489 835 142 4888 2372 433 3096 33 1232 682 902 125 123

Sequence


Ensembl Acc Id: ENSRNOT00000073659   ⟹   ENSRNOP00000066615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl98,052,210 - 8,198,800 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080314   ⟹   ENSRNOP00000069521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl98,093,262 - 8,183,530 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081513   ⟹   ENSRNOP00000073279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl910,085,352 - 10,240,229 (+)Ensembl
mRatBN7.2 Ensembl99,760,355 - 9,900,760 (+)Ensembl
Rnor_6.0 Ensembl98,054,466 - 8,198,800 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138087   ⟹   ENSRNOP00000106052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl910,085,352 - 10,229,056 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147858   ⟹   ENSRNOP00000111958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl910,097,877 - 10,240,229 (+)Ensembl
RefSeq Acc Id: NM_001007558   ⟹   NP_001007559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,355 - 10,229,057 (+)NCBI
mRatBN7.299,758,203 - 9,901,905 (+)NCBI
Dahl_SR_JrHsd912,811,991 - 12,955,310 (+)NCBI
Lyon_Normotensive912,047,561 - 12,190,896 (+)NCBI
Lyon_Hypertensive912,488,473 - 12,631,803 (+)NCBI
F344_StmMcwi97,082,360 - 7,216,387 (-)NCBI
Rnor_6.098,056,052 - 8,198,800 (+)NCBI
Rnor_5.097,096,164 - 7,239,092 (+)NCBI
Celera95,534,515 - 5,670,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084035   ⟹   XP_038939963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,258 - 10,229,057 (+)NCBI
mRatBN7.299,758,106 - 9,901,908 (+)NCBI
RefSeq Acc Id: XM_063267566   ⟹   XP_063123636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,258 - 10,240,346 (+)NCBI
RefSeq Acc Id: XM_063267567   ⟹   XP_063123637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,281 - 10,229,057 (+)NCBI
RefSeq Acc Id: NP_001007559   ⟸   NM_001007558
- Peptide Label: precursor
- UniProtKB: Q5Y4N7 (UniProtKB/TrEMBL),   A0ABK0LV13 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069521   ⟸   ENSRNOT00000080314
Ensembl Acc Id: ENSRNOP00000066615   ⟸   ENSRNOT00000073659
Ensembl Acc Id: ENSRNOP00000073279   ⟸   ENSRNOT00000081513
RefSeq Acc Id: XP_038939963   ⟸   XM_039084035
- Peptide Label: isoform X3
- UniProtKB: A0ABK0LV13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123636   ⟸   XM_063267566
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K538 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123637   ⟸   XM_063267567
- Peptide Label: isoform X2
- UniProtKB: A0ABK0LV13 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111958   ⟸   ENSRNOT00000147858
Ensembl Acc Id: ENSRNOP00000106052   ⟸   ENSRNOT00000138087
Protein Domains
G-protein coupled receptors family 2 profile   GAIN-B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K538-F1-model_v2 AlphaFold A0A0G2K538 1-681 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696429
Promoter ID:EPDNEW_R6953
Type:single initiation site
Name:Adgre4_1
Description:adhesion G protein-coupled receptor E4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.098,052,309 - 8,052,369EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359641 AgrOrtholog
BioCyc Gene G2FUF-28365 BioCyc
Ensembl Genes ENSRNOG00000050325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081513 ENTREZGENE
  ENSRNOT00000081513.3 UniProtKB/TrEMBL
  ENSRNOT00000138087 ENTREZGENE
  ENSRNOT00000138087.1 UniProtKB/TrEMBL
  ENSRNOT00000147858.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GAIN_B UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_EMR1_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
KEGG Report rno:450235 UniProtKB/TrEMBL
NCBI Gene 450235 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR E4P-RELATED UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
PhenoGen Adgre4 PhenoGen
PRINTS EMR1HORMONER UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/TrEMBL
PROSITE EGF_CA UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050325 RatGTEx
SMART EGF_CA UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0G2K538 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LLS8_RAT UniProtKB/TrEMBL
  A0ABK0LV13 ENTREZGENE, UniProtKB/TrEMBL
  Q5Y4N7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-14 Adgre4  adhesion G protein-coupled receptor E4  Adgre4p  adhesion G protein-coupled receptor E4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-11 Adgre4p  adhesion G protein-coupled receptor E4  Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4  Emr4p  EGF-like module containing, mucin-like, hormone receptor-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-25 Emr4p  EGF-like module containing, mucin-like, hormone receptor-like 4  Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4      Symbol and Name status set to provisional 70820 PROVISIONAL