Adgre4 (adhesion G protein-coupled receptor E4) - Rat Genome Database

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Gene: Adgre4 (adhesion G protein-coupled receptor E4) Rattus norvegicus
Analyze
Symbol: Adgre4
Name: adhesion G protein-coupled receptor E4
RGD ID: 1359641
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cell surface. Orthologous to human ADGRE4P (adhesion G protein-coupled receptor E4, pseudogene); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adgre4p; EGF-like module containing, mucin-like, hormone receptor-like 4; EGF-like module containing, mucin-like, hormone receptor-like sequence 4; EGF-like module-containing mucin-like hormone receptor-like 4; Emr4; Emr4p
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8910,085,258 - 10,240,346 (+)NCBIGRCr8
mRatBN7.299,758,106 - 9,901,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl99,760,355 - 9,900,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx912,789,876 - 12,922,137 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0917,028,384 - 17,160,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0915,790,355 - 15,922,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.098,056,034 - 8,200,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl98,052,210 - 8,198,800 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.097,096,164 - 7,239,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera95,534,515 - 5,670,994 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (ISO)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12023293   PMID:15578266  


Genomics

Comparative Map Data
Adgre4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8910,085,258 - 10,240,346 (+)NCBIGRCr8
mRatBN7.299,758,106 - 9,901,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl99,760,355 - 9,900,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx912,789,876 - 12,922,137 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0917,028,384 - 17,160,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0915,790,355 - 15,922,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.098,056,034 - 8,200,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl98,052,210 - 8,198,800 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.097,096,164 - 7,239,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera95,534,515 - 5,670,994 (+)NCBICelera
Cytogenetic Map9q12NCBI
ADGRE4P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,950,758 - 6,997,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,954,659 - 6,990,798 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,950,769 - 6,997,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,903,511 - 6,941,857 (-)NCBINCBI36Build 36hg18NCBI36
Celera196,893,527 - 6,932,800 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef196,715,080 - 6,753,367 (-)NCBIHuRef
CHM1_1196,952,322 - 6,990,906 (-)NCBICHM1_1
T2T-CHM13v2.0196,940,057 - 6,988,111 (-)NCBIT2T-CHM13v2.0
Adgre4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,056,984 - 56,160,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,056,984 - 56,160,662 (+)EnsemblGRCm39 Ensembl
GRCm381755,749,984 - 55,853,662 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1755,749,984 - 55,853,662 (+)EnsemblGRCm38mm10GRCm38
MGSCv371755,889,249 - 55,992,927 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,343,122 - 55,446,606 (+)NCBIMGSCv36mm8
Celera1759,168,585 - 59,272,252 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1728.98NCBI
EMR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,342,233 - 53,385,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,342,420 - 53,377,610 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,091,017 - 53,128,023 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,993,706 - 54,037,282 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,820,811 - 54,029,551 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,063,265 - 53,098,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,510,867 - 53,546,060 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,741,897 - 53,777,089 (-)NCBIUU_Cfam_GSD_1.0
LOC100522787
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1272,071,804 - 72,113,035 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,440,469 - 72,479,902 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Adgre4
1826 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:87
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000073659
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 2
Low 2 6 51 35 8 35 6 6 9 10 11 6
Below cutoff 1 28 6 6 6 2 4 36 24 28 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073659   ⟹   ENSRNOP00000066615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl98,052,210 - 8,198,800 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080314   ⟹   ENSRNOP00000069521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl98,093,262 - 8,183,530 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081513   ⟹   ENSRNOP00000073279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl99,760,355 - 9,900,760 (+)Ensembl
Rnor_6.0 Ensembl98,054,466 - 8,198,800 (+)Ensembl
RefSeq Acc Id: NM_001007558   ⟹   NP_001007559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,355 - 10,229,057 (+)NCBI
mRatBN7.299,758,203 - 9,901,905 (+)NCBI
Rnor_6.098,056,052 - 8,198,800 (+)NCBI
Rnor_5.097,096,164 - 7,239,092 (+)NCBI
Celera95,534,515 - 5,670,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084035   ⟹   XP_038939963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,258 - 10,229,057 (+)NCBI
mRatBN7.299,758,106 - 9,901,908 (+)NCBI
RefSeq Acc Id: XM_063267566   ⟹   XP_063123636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,258 - 10,240,346 (+)NCBI
RefSeq Acc Id: XM_063267567   ⟹   XP_063123637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,085,281 - 10,229,057 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001007559   ⟸   NM_001007558
- Peptide Label: precursor
- UniProtKB: Q5Y4N7 (UniProtKB/TrEMBL),   A0A0G2K538 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069521   ⟸   ENSRNOT00000080314
RefSeq Acc Id: ENSRNOP00000066615   ⟸   ENSRNOT00000073659
RefSeq Acc Id: ENSRNOP00000073279   ⟸   ENSRNOT00000081513
RefSeq Acc Id: XP_038939963   ⟸   XM_039084035
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K538 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123636   ⟸   XM_063267566
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123637   ⟸   XM_063267567
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K538-F1-model_v2 AlphaFold A0A0G2K538 1-681 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696429
Promoter ID:EPDNEW_R6953
Type:single initiation site
Name:Adgre4_1
Description:adhesion G protein-coupled receptor E4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.098,052,309 - 8,052,369EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359641 AgrOrtholog
BioCyc Gene G2FUF-28365 BioCyc
Ensembl Genes ENSRNOG00000050325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081513 ENTREZGENE
  ENSRNOT00000081513.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_EMR1_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
KEGG Report rno:450235 UniProtKB/TrEMBL
NCBI Gene 450235 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR E4P-RELATED UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
PhenoGen Adgre4 PhenoGen
PRINTS EMR1HORMONER UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/TrEMBL
PROSITE EGF_CA UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050325 RatGTEx
SMART EGF_CA UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0G2K538 ENTREZGENE, UniProtKB/TrEMBL
  Q5Y4N7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-14 Adgre4  adhesion G protein-coupled receptor E4  Adgre4p  adhesion G protein-coupled receptor E4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-11 Adgre4p  adhesion G protein-coupled receptor E4  Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4  Emr4p  EGF-like module containing, mucin-like, hormone receptor-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-25 Emr4p  EGF-like module containing, mucin-like, hormone receptor-like 4  Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Emr4  EGF-like module containing, mucin-like, hormone receptor-like sequence 4      Symbol and Name status set to provisional 70820 PROVISIONAL