ENCODES a protein that exhibits cysteine-type endopeptidase activator activity (ortholog); double-stranded DNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); AIM2 inflammasome complex assemb
ly (ortholog); brain development (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); multiple sclerosis (ortholog); FOUND IN AIM2 inflammasome complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine
ENCODES a protein that exhibits scaffold protein binding; CARD domain binding (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN lung development; memory; microglial cell activation; PARTICIPATES IN interleukin-1 signaling pathway; type II interferon signaling pathway; amyotrop
ENCODES a protein that exhibits protein domain specific binding (ortholog); protein-macromolecule adaptor activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN host-mediated suppression of symbiont invasion (ortholog); innate immune response (ortholog); negative regulation o
f AIM2 inflammasome complex assembly (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol