| 2069 | Agt | angiotensinogen | ENCODES a protein that exhibits hormone activity; growth factor activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN angiotensin-mediated drinking behavior; artery smooth muscle contraction; associative learning; PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II si gnaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; ASSOCIATED WITH anti-basement membrane glomerulonephritis; Aortic Calcification; atherosclerosis; FOUND IN extracellular space; mitochondrion; extracellular region (ortholog); INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone | 19 | 69426540 | 69447017 | Rat | 1230 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2073 | Agxt | alanine--glyoxylate aminotransferase | ENCODES a protein that exhibits alanine-glyoxylate transaminase activity; amino acid binding; L-serine-pyruvate transaminase activity; INVOLVED IN glycine biosynthetic process, by transamination of glyoxylate; pyruvate biosynthetic process; response to cAMP; PARTICIPATES IN alanine metabolic pathway ; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Vitamin B Deficiency; Cardiac Arrhythmias (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix; peroxisome; peroxisomal matrix (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 101122793 | 101132746 | Rat | 197 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 621767 | Agxt2 | alanine-glyoxylate aminotransferase 2 | ENCODES a protein that exhibits (R)-3-amino-2-methylpropionate-pyruvate transaminase activity; alanine-glyoxylate transaminase activity; beta-alanine:pyruvate transaminase activity; INVOLVED IN N(omega),N(omega)-dimethyl-L-arginine catabolic process; glycine biosynthetic process, by transamination o f glyoxylate (ortholog); glyoxylate catabolic process (ortholog); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; glycine, serine and threonine metabolic pathway; ASSOCIATED WITH atrial fibrillation (ortholog); Beta-Aminoisobutyric Acid, Urinary Excretion of (ortholog); Carotid Atherosclerosis (ortholog); FOUND IN mitochondrion; INTERACTS WITH (+)-schisandrin B; 2,2,2-tetramine; 2,4-dinitrotoluene | 2 | 61063416 | 61104828 | Rat | 149 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2072 | Agtr2 | angiotensin II receptor, type 2 | ENCODES a protein that exhibits angiotensin type II receptor activity; transcription factor binding; INVOLVED IN cell growth involved in cardiac muscle cell development; cellular response to dexamethasone stimulus; cerebellar cortex development; PARTICIPATES IN angiotensin III signaling pathway via AT2 receptor; angiotensin II signaling pathway via AT2 receptor; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH Alveolar Bone Loss; asthma; Brain Hypoxia-Ischemia; FOUND IN perinuclear region of cytoplasm; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol | X | 116914320 | 116918504 | Rat | 282 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2070 | Agtr1a | angiotensin II receptor, type 1a | ENCODES a protein that exhibits angiotensin type I receptor activity; D1 dopamine receptor binding; protein kinase binding; INVOLVED IN activation of Janus kinase activity; angiotensin-activated signaling pathway; cellular response to dexamethasone stimulus; PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH decreased angiogenesis; ASSOCIATED WITH Alveolar Bone Loss; anti-basement membrane glomerulonephritis; asthma; FOUND IN basolateral plasma membrane; cytoplasmic vesicle; dendrite; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine | 17 | 34383397 | 34435523 | Rat | 654 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2071 | Agtr1b | angiotensin II receptor, type 1b | ENCODES a protein that exhibits angiotensin type I receptor activity (ortholog); INVOLVED IN angiotensin-activated signaling pathway; cellular response to dexamethasone stimulus; positive regulation of blood pressure; PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; angiotensin III signaling pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Cardiomegaly; hypertension; Postoperative Cognitive Dysfunction; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH (+)-taxifolin; (S)-nicotine; 17beta-estradiol | 2 | 104774005 | 104849262 | Rat | 103 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1359346 | Agtrap | angiotensin II receptor-associated protein | ENCODES a protein that exhibits angiotensin type II receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN response to hypoxia; regulation of blood pressure (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; ASSOCIATED WITH increased urine protein level; ASSOCIATED WITH Cardiomegaly; hypertension; acquired metabolic disease (ortholog); FOUND IN cell cortex (ortholog); Golgi apparatus (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chlormequat chloride | 5 | 163790565 | 163802174 | Rat | 88 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306307 | Agtpbp1 | ATP/GTP binding carboxypeptidase 1 | ENCODES a protein that exhibits metallocarboxypeptidase activity (ortholog); tubulin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); anterograde axonal transport of mitochondrion (ortholog); axonal transport (ortholog); ASSOCIATED WITH Childhood-Onset Neurodegeneration with Cerebe llar Atrophy (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 17 | 5092108 | 5244414 | Rat | 149 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 5508331 | Agtr1aem1Mcwi | angiotensin II receptor, type 1a; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is a 2-bp frameshift deletion in exon 3 (del 521-523) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 5508318 | Agtr1aem5Mcwi | angiotensin II receptor, type 1a; zinc finger nuclease induced mutant 5, Medical College of Wisconsin | ASSOCIATED WITH decreased angiogenesis | | | | Rat | 1 | symbol , old_gene_symbol | gene, allele |
| 5143963 | Agtrapem4Mcwi | angiotensin II receptor-associated protein; zinc finger nuclease induced mutant 4, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is a 100-bp mutation deleting part of exon 3 and the splice acceptor (del 165157844-165157927) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 5143970 | Agtrapem8Mcwi | angiotensin II receptor-associated protein; zinc finger nuclease induced mutant 8, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is a 100-bp mutation deleting part of exon 3 and the splice acceptor (del 165157761-165157860) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1578784 | Agtr1bm1Mcwi | angiotensin II receptor, type 1b; mutation 1, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); a 3bp deletion generates a mutation at TTC (del251F) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1596915 | Atg4a | autophagy related 4A, cysteine peptidase | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); protein-phosphatidylethanolamide deconjugating activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); protein delipidation (ortholog); PARTICIPATES IN autophagy pathway; FOUND IN cytoplasm (inferred); INTERACTS WITH bisphenol A; vinclozolin; (-)-epigallocatechin 3-gallate (ortholog) | X | 109453712 | 109553758 | Rat | 76 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 621645 | Aplnr | apelin receptor | ENCODES a protein that exhibits mechanoreceptor activity; apelin receptor activity (ortholog); G protein-coupled peptide receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; regulation of bo dy fluid levels; PARTICIPATES IN apelin signaling pathway; ASSOCIATED WITH type 2 diabetes mellitus (ortholog); FOUND IN plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol | 3 | 90624055 | 90627700 | Rat | 196 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1359472 | Rdx | radixin | ENCODES a protein that exhibits actin binding; protein kinase A binding; ATPase binding (ortholog); INVOLVED IN apical protein localization; barbed-end actin filament capping; cellular response to platelet-derived growth factor stimulus; ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ort holog); autosomal recessive nonsyndromic deafness 24 (ortholog); cholestasis (ortholog); FOUND IN adherens junction; cell tip; cleavage furrow; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 8 | 61275792 | 61348260 | Rat | 250 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1581476 | Adora2am1Mcwi | adenosine A2a receptor; mutation 1, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); C249S mutation is generated from the codon change TGT/AGT | | | | Rat | | description | gene, allele |
| 1579888 | Ccr2m1Mcwi | C-C motif chemokine receptor 2; mutation 1, Medical College of Wisconsin | Mutation generated by ENU (N-ethyl-N-nitrourea); N117S mutation is generated from the codon change AAT/AGT. | | | | Rat | | description | gene, allele |
| 620672 | Apln | apelin | ENCODES a protein that exhibits apelin receptor binding; identical protein binding; hormone activity (ortholog); INVOLVED IN apelin receptor signaling pathway; drinking behavior; feeding behavior; PARTICIPATES IN apelin signaling pathway; ASSOCIATED WITH Cardiomegaly; colitis; congestive heart failu re; FOUND IN extracellular space; perinuclear region of cytoplasm; extracellular region (ortholog); INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | X | 132058739 | 132091518 | Rat | 236 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 151347430 | Mstnem1Cqin | myostatin; ZFN induced mutant 1, Cqin | ASSOCIATED WITH increased body weight | | | | Rat | 1 | description | gene, allele |