RGD Reference Report - Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats. - Rat Genome Database

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Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats.

Authors: Lee, JH  Pradhan, J  Maskey, D  Park, KS  Hong, SH  Suh, MW  Kim, MJ  Ahn, SC 
Citation: Lee JH, etal., Biochem Biophys Res Commun. 2011 Feb 11;405(2):162-7. doi: 10.1016/j.bbrc.2010.12.129. Epub 2011 Jan 5.
RGD ID: 9999192
Pubmed: PMID:21215254   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2010.12.129   (Journal Full-text)

Cochlear dependency of glutamate co-transmission at the medial nucleus of the trapezoid body (MNTB)--the lateral superior olive (LSO) synapses was investigated using developing rats treated with high dose kanamycin. Rats were treated with kanamycin from postnatal day (P) 3 to P8. A scanning electron microscopic study on P9 demonstrated partial cochlear hair cell damage. A whole cell voltage clamp experiment demonstrated the increased glutamatergic portion of postsynaptic currents (PSCs) elicited by MNTB stimulation in P9-P11 kanamycin-treated rats. The enhanced VGLUT3 immunoreactivities (IRs) in kanamycin-treated rats and asymmetric VGLUT3 IRs in the LSO of unilaterally cochlear ablated rats supported the electrophysiologic data. Taken together, it is concluded that glutamate co-transmission is cochlear-dependent and enhanced glutamate co-transmission in kanamycin-treated rats is induced by partial cochlear damage.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cochlear disease  ISOSlc17a8 (Rattus norvegicus)9999192; 9999192 RGD 
cochlear disease  IEP 9999192 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a8  (solute carrier family 17 member 8)

Genes (Mus musculus)
Slc17a8  (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)

Genes (Homo sapiens)
SLC17A8  (solute carrier family 17 member 8)


Additional Information