RGD Reference Report - Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. - Rat Genome Database

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Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells.

Authors: Christa, L  Simon, MT  Brezault-Bonnet, C  Bonte, E  Carnot, F  Zylberberg, H  Franco, D  Capron, F  Roskams, T  Brechot, C 
Citation: Christa L, etal., Am J Pathol. 1999 Nov;155(5):1525-33.
RGD ID: 9831380
Pubmed: PMID:10550309   (View Abstract at PubMed)
PMCID: PMC1866987   (View Article at PubMed Central)
DOI: DOI:10.1016/S0002-9440(10)65468-5   (Journal Full-text)

Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) gene was identified because of its increased expression in 25% of human hepatocellular carcinoma. HIP/PAP protein, a C-type lectin, binds laminin, acts as an adhesion molecule for hepatocytes, and has also been described as an acute phase secretory protein during acute pancreatitis in humans and rats. We investigated HIP/PAP protein expression in patients with various liver diseases associated with ductular reaction. At the same time, we analyzed patients with hepatocellular carcinoma and cholangiocarcinoma, and tested HIP/PAP protein levels in sera to establish the pattern of secretion. Our data show that HIP/PAP expression was not restricted to hepatocellular carcinoma, but was also detected in cholangiocarcinoma cells as well as in reactive non-malignant bile ductules. In contrast, HIP/PAP protein expression was undetectable in normal mature hepatocytes, but some ductular cells localized at the interface of portal tracts with parenchyma were HIP/PAP immunoreactive in normal liver. Finally, we present evidence that HIP/PAP serum levels were increased in 21/28 (75%) patients with hepatocellular carcinoma, and in 25/51 (49%) patients with nonmalignant cirrhosis. Altogether, these results suggest that HIP/PAP protein may be implicated in hepatocytic and cholangiolar differentiation and proliferation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma  IEP 9831380mRNA:increased expression:liver (human)RGD 
hepatocellular carcinoma  ISOREG3A (Homo sapiens)9831380; 9831380mRNA:increased expression:liver (human)RGD 
liver cirrhosis  IEP 9831380protein:increased expression:serum (human)RGD 
liver cirrhosis  ISOREG3A (Homo sapiens)9831380; 9831380protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Reg3b  (regenerating family member 3 beta)

Genes (Mus musculus)
Reg3b  (regenerating islet-derived 3 beta)

Genes (Homo sapiens)
REG3A  (regenerating family member 3 alpha)


Additional Information