RGD Reference Report - Hippocampal ether-a-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition. - Rat Genome Database

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Hippocampal ether-a-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition.

Authors: Issy, AC  Fonseca, JR  Pardo, LA  Stuhmer, W  Del Bel, EA 
Citation: Issy AC, etal., Neurosci Lett. 2014 Jan 24;559:13-7. doi: 10.1016/j.neulet.2013.11.026. Epub 2013 Nov 24.
RGD ID: 9693684
Pubmed: PMID:24284010   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2013.11.026   (Journal Full-text)

Recently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K(+)) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. The increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. The PPI response has been reported to be abnormally reduced in schizophrenia patients. The role of Eag1 K(+) channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. The aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K(+) channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
startle response  IMP 9693684 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnh1  (potassium voltage-gated channel subfamily H member 1)


Additional Information