RGD Reference Report - CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes. - Rat Genome Database

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CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes.

Authors: Kim, KC  Hyun Joo, S  Shin, CY 
Citation: Kim KC, etal., Biochem Biophys Res Commun. 2011 Jun 17;409(4):687-92. doi: 10.1016/j.bbrc.2011.05.065. Epub 2011 May 17.
RGD ID: 9685153
Pubmed: PMID:21620800   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2011.05.065   (Journal Full-text)

Upon CNS damage, astrocytes undergo a series of biological changes including increased proliferation, production of inflammatory mediators and morphological changes, in a response collectively called reactive gliosis. This process is an essential part of the brains response to injury, yet much is unknown about the molecular mechanism(s) that induce these changes. In this study, we investigated the role of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in the regulation of inflammatory responses in a model of reactive gliosis, lipopolysaccharide-stimulated astrocytes. CPEB1 is an mRNA-binding protein recently shown to be expressed in astrocytes that may play a role in astrocytes migration. After LPS stimulation, the expression and phosphorylation of CPEB1 was increased in rat primary astrocytes in a JNK-dependent process. siRNA-induced knockdown of CPEB1 expression inhibited the LPS-induced up-regulation of iNOS as well as NO and ROS production, a hallmark of immunological activation of astrocytes. The results from the study suggest that CPEB1 is actively involved in the regulation of inflammatory responses in astrocytes, which might provide new insights into the regulatory mechanism after brain injury.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to lipopolysaccharide  IEP 9685153 RGD 
positive regulation of nitric-oxide synthase biosynthetic process  IMP 9685153 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cpeb1  (cytoplasmic polyadenylation element binding protein 1)


Additional Information