RGD Reference Report - Diagnosis and assessment of Takayasu arteritis by multiple biomarkers. - Rat Genome Database

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Diagnosis and assessment of Takayasu arteritis by multiple biomarkers.

Authors: Ishihara, T  Haraguchi, G  Tezuka, D  Kamiishi, T  Inagaki, H  Isobe, M 
Citation: Ishihara T, etal., Circ J. 2013;77(2):477-83. Epub 2012 Oct 26.
RGD ID: 8693315
Pubmed: PMID:23100088   (View Abstract at PubMed)

BACKGROUND: Patients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established. METHODS AND RESULTS: We enrolled 45 consecutive patients; 28 were grouped in an active phase as evidenced by clinical recurrence within 2 years of blood sampling. Circulating levels of high-sensitivity (hs)CRP, MMPs, and PTX3 were determined. Patients in an active phase showed higher levels of hsCRP, MMP-9, and PTX3. Area under the receiving operating characteristics curves of hsCRP and PTX3 were significantly higher than that of MMP-9. Among the 28 patients with active TA, 71% was positive for hsCRP and 82% for PTX3. Patients without recurrence showed significantly higher plasma levels of MMP-9. There was a positive correlation between the plasma MMP-3 level and the prednisolone dose. However, PTX3 and MMP-9 levels did not have such a correlation. CONCLUSIONS: PTX3 and MMP-9, which are not affected by prednisolone, could be sensitive biomarkers for assessing TA activity. Evaluation of MMP-9 may suggest prior existence of TA.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Takayasu's arteritis treatmentIEP 8693315 RGD 
Takayasu's arteritis disease_progressionIEP 8693315 RGD 
Takayasu's arteritis treatmentISOMMP3 (Homo sapiens)8693315; 8693315 RGD 
Takayasu's arteritis disease_progressionISOMMP9 (Homo sapiens)8693315; 8693315 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp3  (matrix metallopeptidase 3)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp3  (matrix metallopeptidase 3)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP3  (matrix metallopeptidase 3)
MMP9  (matrix metallopeptidase 9)


Additional Information