RGD Reference Report - [Pigment epithelium-derived factor expression in the retina in response to hypobaric hypoxia]. - Rat Genome Database

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[Pigment epithelium-derived factor expression in the retina in response to hypobaric hypoxia].

Authors: Zhang, Y  Yuan, YS  Xu, L  Yuan, LL 
Citation: Zhang Y, etal., Zhonghua Yan Ke Za Zhi. 2007 Dec;43(12):1130-4.
RGD ID: 8655558
Pubmed: PMID:18331686   (View Abstract at PubMed)

OBJECTIVE: The present study was undertaken to examine the expression of pigment epithelium-derived factor (PEDF) in the retina of adult rat following hypobaric hypoxic exposures. METHODS: Forty-eight adult Wistar rats were divided into 6 groups randomly (8 rats in each group), of which 5 groups (40 rats) were subjected to hypobaric hypoxia for 2 hours following which expression of PEDF in the retina was investigated from 3 hours to 14 days by real time RT-PCR, western blotting and immunohistochemistry. RESULTS: PEDF mRNA and protein expression in the retina was decreased at 3 hours to 14 days following exposure to hypoxia. Compared with normal control group (1.00+/-0.00), PEDF mRNA expression decreased to 0.83+/-0.05 at 3 hours, 0.72+/-0.04 at 24 hours, 0.56+/-0.04 at 3 days, 0.54+/-0.05 at 7 days and 0.49+/-0.05 at 14 days respectively; Compared with normal control group (1.90+/-0.02), PEDF protein expression decreased to 1.49+/-0.02 at 3 hours, 1.19+/-0.05 at 24 hours, 1.15+/-0.05 at 3 days, 1.09+/-0.06 at 7 days and 1.07+/-0.03 at 14 days respectively. CONCLUSIONS: The findings of this study indicate hypoxia can downregulate PEDF in adult retina.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypoxia  ISOSerpinf1 (Rattus norvegicus)8655558; 8655558mRNA and protein:decreased expression:retina (rat)RGD 
Hypoxia  IEP 8655558mRNA and protein:decreased expression:retina (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinf1  (serpin family F member 1)

Genes (Mus musculus)
Serpinf1  (serine (or cysteine) peptidase inhibitor, clade F, member 1)

Genes (Homo sapiens)
SERPINF1  (serpin family F member 1)


Additional Information