RGD Reference Report - Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. - Rat Genome Database

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Identification and characterisation of the novel amyloid-beta peptide-induced protein p17.

Authors: Nehar, S  Mishra, M  Heese, K 
Citation: Nehar S, etal., FEBS Lett. 2009 Oct 6;583(19):3247-53. doi: 10.1016/j.febslet.2009.09.018. Epub 2009 Sep 13.
RGD ID: 8553945
Pubmed: PMID:19755123   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2009.09.018   (Journal Full-text)

Amyloid-beta peptide (Abeta) achieves neurodegeneration through unknown mechanisms. To elucidate some of these mechanisms, we conducted a cDNA subtraction analysis of Abeta-mediated neurotoxicity in neuronal cells and observed an up-regulation of the novel gene p17. The p17 protein was also found elevated in Alzheimer's disease (AD) mouse model. Here, we characterised p17 primarily in cell lines with respect to its localisation, function and physiological expression. We discovered that p17 acts downstream of protein kinase C and inhibits the tyrosine receptor kinase B-brain-derived neurotrophic factor (TrkB-BDNF) pathway. It impedes survival factors and enhances amyloid precursor protein expression thus suggesting its involvement in the Abeta-mediated pro-apoptotic pathways in AD.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of apoptotic process acts_upstream_of_or_withinIDA 8553945PMID:19755123MGI 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cytosol located_inIDA 8553945PMID:19755123MGI 
membrane located_inIDA 8553945PMID:19755123MGI 

Objects Annotated

Genes (Rattus norvegicus)
Fam72a  (family with sequence similarity 72, member A)


Additional Information