RGD Reference Report - The association between copy number variations in glutathione S-transferase M1 and T1 and age-related cataract in a Han Chinese population. - Rat Genome Database

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The association between copy number variations in glutathione S-transferase M1 and T1 and age-related cataract in a Han Chinese population.

Authors: Zhou, J  Hu, J  Guan, H 
Citation: Zhou J, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3924-8. doi: 10.1167/iovs.10-5240. Epub 2010 Mar 24.
RGD ID: 7794821
Pubmed: PMID:20335620   (View Abstract at PubMed)
DOI: DOI:10.1167/iovs.10-5240   (Journal Full-text)

PURPOSE: To determine the contribution of copy number variation (CNV) in glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) to the susceptibility to age-related cataract (ARC) and its subtypes in a Han Chinese population. METHODS: ARC cases (n = 279) and controls (n = 145) were included from a Han Chinese population-based prospective study. Quantitative RT-PCR and the DeltaCt method were used to determine the presence of no, one, or multiple alleles of GSTM1 and GSTT1. The RNaseP gene was used as the internal control. RESULTS: The GSTT1 null genotype was associated with ARC with an odds ratio (OR) of 1.56 (P < 0.05). Deletion of at least one GSTT1 allele also influenced the onset of ARC (OR = 2.16, P < 0.01). Consistent associations were observed between GSTT1 CNV and cortical cataract. The deletion of at least one GSTT1 allele was associated with an OR of 4.81 for developing cortical ARC (P < 0.001), although individuals who had more than two copies of GSTT1 had a reduced risk of cortical ARC (OR = 0.19, P < 0.05). The frequency of the GSTT1 null genotype in the Han Chinese population differed dramatically from that in Caucasians. No association was detected between GSTM1 CNV and ARC. CONCLUSIONS: An association was observed between GSTT1 CNV and ARC in a Han Chinese population. The GSTT1 CNV is most closely associated with cortical cataract risk. The loss of at least one GSTT1 allele increases the risk of cortical cataract, whereas gain in GSTT1 copy number reduces the risk.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cataract susceptibilityIAGP 7794821DNA:deletion:cds (human)RGD 
cataract susceptibilityISOGSTT1 (Homo sapiens)7794821; 7794821DNA:deletion:cds (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal lens morphology susceptibilityIAGP 7794821DNA:deletion:cds:RGD 
Visual acuity test abnormality susceptibilityIAGP 7794821DNA:deletion:cds:RGD 
Objects Annotated

Genes (Rattus norvegicus)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTT1  (glutathione S-transferase theta 1)


Additional Information