RGD Reference Report - The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. - Rat Genome Database

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The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

Authors: Demidov, ON  Kek, C  Shreeram, S  Timofeev, O  Fornace, AJ  Appella, E  Bulavin, DV 
Citation: Demidov ON, etal., Oncogene. 2007 Apr 12;26(17):2502-6. Epub 2006 Oct 2.
RGD ID: 7495832
Pubmed: PMID:17016428   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.onc.1210032   (Journal Full-text)

There is increasing evidence for the role of wild-type p53 induced phosphatase 1 (Wip1) phosphatase in the regulation of tumorigenesis. To evaluate Wip1 as a breast cancer oncogene, we generated a mouse strain with targeted expression of Wip1 to the breast epithelium. We found that these mice are prone to cancer when intercrossed with transgenics expressing the ErbB2 oncogene but not conditional knockouts for Brca2. This tumor-prone phenotype of Wip1 is fully eliminated through attenuation of proliferation by activating the MKK6/p38 mitogen-activated protein kinases (MAPK) cascade in mice bearing a constitutively active form of MKK6. We propose that Wip1 phosphatase operates within the MKK6/p38 MAPK signaling pathway to promote ErbB2-driven mammary gland tumorigenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Animal Mammary Neoplasms  ISOMap2k6 (Mus musculus)7495832; 7495832 RGD 
Animal Mammary Neoplasms  IGIPpm1d (Mus musculus)7495832 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Map2k6  (mitogen-activated protein kinase kinase 6)

Genes (Mus musculus)
Map2k6  (mitogen-activated protein kinase kinase 6)

Genes (Homo sapiens)
MAP2K6  (mitogen-activated protein kinase kinase 6)


Additional Information