RGD Reference Report - Up-regulation of chemokine ligand 20 in chronic rhinosinusitis. - Rat Genome Database

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Up-regulation of chemokine ligand 20 in chronic rhinosinusitis.

Authors: Lee, JH  Kang, HJ  Woo, JS  Chae, SW  Lee, SH  Hwang, SJ  Lee, HM 
Citation: Lee JH, etal., Arch Otolaryngol Head Neck Surg. 2006 May;132(5):537-41.
RGD ID: 7483585
Pubmed: PMID:16702571   (View Abstract at PubMed)
DOI: DOI:10.1001/archotol.132.5.537   (Journal Full-text)

OBJECTIVES: To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. DESIGN: Prospective study. SETTING: Tertiary academic institution. PATIENTS: Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal control subjects. INTERVENTIONS: Messenger RNA was extracted from the sinus mucosa, and semiquantitative reverse transcriptase-polymerase chain reaction was performed. Immunohistochemical staining was used to localize the CCL20 protein. RESULTS: The expression levels of CCL20 messenger RNA level in chronic rhinosinusitis without nasal polyps were significantly increased compared with those in normal sinus mucosa. The expression of CCL20 protein was greater in chronic rhinosinusitis without nasal polyps mucosa and was localized to the epithelial and submucosal glandular cells. CONCLUSION: CCL20 is an inducible product of human paranasal sinus epithelium that may play a role in modulating mucosal immunity of the sinus mucosa.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Rhinosinusitis  IEP 7483585 RGD 
Rhinosinusitis  ISOCCL20 (Homo sapiens)7483585; 7483585 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl20  (C-C motif chemokine ligand 20)

Genes (Mus musculus)
Ccl20  (C-C motif chemokine ligand 20)

Genes (Homo sapiens)
CCL20  (C-C motif chemokine ligand 20)


Additional Information