RGD Reference Report - [Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium]. - Rat Genome Database

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[Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium].

Authors: Lü, Haili  Guo, Yongqing  Dong, Zhen 
Citation: Lü H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Nov;18(11):649-50.
RGD ID: 7364740
Pubmed: PMID:15715404   (View Abstract at PubMed)


OBJECTIVE: To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis.
METHOD: With immunohistochemistry ABC and HE dyeing, twenty-seven polyps, nineteen chronic hypertrophy rhinitis and eleven normal inferior turbinates epithelium were applied to this study.
RESULT: The number of MUC5AC+ cells in nasal polyps and chronic hypertrophy rhinitis was significantly bigger than that in normal inferior turbinates (P < 0.05), and the MUC5AC+ cells were mainly concentrate on the goblet cells.
CONCLUSION: MUC5AC is highly expressed in epithelium of human polyps and chronic hypertrophy rhinitis inferior turbinates, and MUC5AC takes part in increasing secretion in polyps and chronic hypertrophy rhinitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nasal Polyps  IEP 7364740 RGD 
Nasal Polyps  ISOMUC5AC (Homo sapiens)7364740; 7364740 RGD 
rhinitis  IEP 7364740 RGD 
rhinitis  ISOMUC5AC (Homo sapiens)7364740; 7364740 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc5ac  (mucin 5AC, oligomeric mucus/gel-forming)

Genes (Mus musculus)
Muc5ac  (mucin 5, subtypes A and C, tracheobronchial/gastric)

Genes (Homo sapiens)
MUC5AC  (mucin 5AC, oligomeric mucus/gel-forming)


Additional Information