RGD Reference Report - A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells. - Rat Genome Database

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A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells.

Authors: Takumi, T  Ishii, T  Horio, Y  Morishige, K  Takahashi, N  Yamada, M  Yamashita, T  Kiyama, H  Sohmiya, K  Nakanishi, S 
Citation: Takumi T, etal., J Biol Chem 1995 Jul 7;270(27):16339-46.
RGD ID: 729280
Pubmed: PMID:7608203   (View Abstract at PubMed)

We have isolated a novel inward rectifier K+ channel predominantly expressed in glial cells of the central nervous system. Its amino acid sequence exhibited 53% identity with ROMK1 and approximately 40% identity with other inward rectifier K+ channels. Xenopus oocytes injected with cRNA derived from this clone expressed a K+ current, which showed classical inward rectifier K+ channel characteristics. Intracellular Mg.ATP was required to sustain channel activity in excised membrane patches, which is consistent with a Walker type-A ATP-binding domain on this clone. We designate this new clone as KAB-2 (the second type of inward rectifying K+ channel with an ATP-binding domain). In situ hybridization showed KAB-2 mRNA to be expressed predominantly in glial cells of the cerebellum and forebrain. This is the first description of the cloning of a glial cell inward rectifier potassium channel, which may be responsible for K+ buffering action of glial cells in the brain.

Objects referenced in this article
Gene Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus

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