RGD Reference Report - [Changes in nitric oxide, prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats]. - Rat Genome Database

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[Changes in nitric oxide, prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats].

Authors: Linares-Fernandez, B  Alfieri, AB 
Citation: Linares-Fernandez B and Alfieri AB, Invest Clin. 2009 Mar;50(1):23-33.
RGD ID: 7174704
Pubmed: PMID:19418724   (View Abstract at PubMed)

To investigate the role of substance P (sP), nitric oxide (ON) and prostaglandins (PGs) in acrolein (ACR)-induced cystitis, we studied the changes induced by ACR on bladder inducible nitric oxide synthase (iNOS) and mieloperoxidase (MPO) activities, along with PGs and NO metabolites levels. Sprague-Dawley male rats received i.p. ACR (5 mg/Kg) plus one of the following treatments: Group 1: saline 0.10 mL/100g i.p.; Group 2: Win-51.708 (WIN) 25 mg/Kg i.p.; Group 3: S-metilisothiourea (MITU) 35 mg/Kg i.p.; Group 4: Rofecoxib(ROF) 20 mg/Kg o.p.; Group 5: Meloxicam(MEL) 25 mg/Kg i.p.; Group 6: combination MITU+MEL. ACR-induced mortality was partially prevented by WIN (NK1 antagonist) and MITU (iNOS inhibitor). Animals that survived after 24h of ACR exposure, had histological inflammatory changes in bladder along with increased MPO activity. There was augmentation of nitrates+nitrites and of PGs. WIN didn't prevent any of these effects. ROF and MEL (COX-2 inhibitors) partially protected against bladder inflammation; MITU pre-treatment was able to prevent these changes and those of NO metabolites levels. The MITU+MEL combination produced the highest protection against ACR-induced damage. These results suggest that NO produced via iNOS and PGs produced by COX-1/COX-2, have an important role in the pathogenesis of cystitis induced by ACR. ACR could stimulate iNOS and COX-1/COX-2, producing lymphocyte migration and increases of NO and PGs.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MPOHumancystitis  ISOMpo (Rattus norvegicus)protein:increased activity:bladderRGD 
MpoMousecystitis  ISOMpo (Rattus norvegicus)protein:increased activity:bladderRGD 
MpoRatcystitis  IEP protein:increased activity:bladderRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mpo  (myeloperoxidase)

Genes (Mus musculus)
Mpo  (myeloperoxidase)

Genes (Homo sapiens)
MPO  (myeloperoxidase)


Additional Information