RGD Reference Report - Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. - Rat Genome Database

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Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet.

Authors: Picard, F  Boivin, A  Lalonde, J  Deshaies, Y 
Citation: Picard F, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E412-8.
RGD ID: 70246
Pubmed: PMID:11788374   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpendo.00307.2001   (Journal Full-text)

This study aimed to assess whether adipose lipoprotein lipase (LPL) becomes resistant to insulin in a nutritional model of resistance of glucose metabolism to insulin. Sprague-Dawley rats were fed for 4 wk chow or a purified high-sucrose, high-fat (HSHF) diet that induced overt insulin resistance. Rats were fasted for 24 h and then refed chow for 1, 3, or 6 h. The postprandial rise in insulinemia was similar in both dietary cohorts, whereas glycemia was higher in HSHF-fed than in chow-fed animals, indicating glucose intolerance and insulin resistance. In chow-fed rats, adipose LPL activity increased two- to fourfold postprandially, but only minimally (30%) in HSHF-fed rats. Muscle LPL decreased postprandially in HSHF-fed rats, suggesting intact sensitivity to insulin, but it increased in chow-fed animals. Peak postprandial triglyceridemia was higher (+70%) in insulin-resistant than in control rats. The postprandial rate of appearance of triglycerides in the circulation was similar in control and insulin-resistant rats, indicating that hypertriglyceridemia of the latter was the result of impaired clearance. These results demonstrate that adipose LPL becomes resistant to insulin in diet-induced IR and further suggest that, under certain nutritional conditions, modifications in adipose LPL modulation associated with insulin resistance, along with low muscle LPL, heightens postprandial hypertriglyceridemia through attenuated triglyceride clearance.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
triglyceride biosynthetic process  IMP 70246 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lipoprotein lipase activity  IDA 70246 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lpl  (lipoprotein lipase)


Additional Information