RGD Reference Report - Soluble urokinase plasminogen activator receptor (suPAR) is associated with metabolic changes in HIV-1-infected africans: a prospective study. - Rat Genome Database

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Soluble urokinase plasminogen activator receptor (suPAR) is associated with metabolic changes in HIV-1-infected africans: a prospective study.

Authors: Fourie, CM  Van Rooyen, JM  Kruger, A  Olsen, MH  Eugen-Olsen, J  Schutte, R  Schutte, AE 
Citation: Fourie CM, etal., Inflammation. 2012 Feb;35(1):221-9.
RGD ID: 6484120
Pubmed: PMID:21384094   (View Abstract at PubMed)
DOI: DOI:10.1007/s10753-011-9308-6   (Journal Full-text)

Soluble urokinase plasminogen activator receptor (suPAR) is associated with inflammation and may predict lipodystrophy and dysmetabolism in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy. We aimed to assess firstly, whether suPAR levels are elevated in treated and untreated HIV-1-infected Africans compared to uninfected controls at baseline and at a 3-year follow-up, and secondly whether suPAR levels are correlated with cardiovascular and/or metabolic changes. SuPAR, cardiovascular, and metabolic variables were assessed and the percentage change was determined. HIV-1-infected black South Africans had significantly higher suPAR levels than uninfected controls at baseline and at follow-up 3 years later. However, only the treated HIV-1-infected participants showed an increase in suPAR levels at follow-up. The treated group also showed signs of lipodystrophy and their baseline suPAR levels correlated positively with an increased waist circumference. This study indicates that suPAR levels increase and that baseline suPAR is associated with an increase in abdominal fat distribution in HIV-infected black Africans on antiretroviral therapy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
human immunodeficiency virus infectious disease  IEP 6484120protein:increased expression:plasmaRGD 
human immunodeficiency virus infectious disease  ISOPLAUR (Homo sapiens)6484120; 6484120protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Plaur  (plasminogen activator, urokinase receptor)

Genes (Mus musculus)
Plaur  (plasminogen activator, urokinase receptor)

Genes (Homo sapiens)
PLAUR  (plasminogen activator, urokinase receptor)


Additional Information