RGD Reference Report - The sodium-activated potassium channel is encoded by a member of the Slo gene family. - Rat Genome Database

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The sodium-activated potassium channel is encoded by a member of the Slo gene family.

Authors: Yuan, A  Santi, CM  Wei, A  Wang, ZW  Pollak, K  Nonet, M  Kaczmarek, L  Crowder, CM  Salkoff, L 
Citation: Yuan A, etal., Neuron 2003 Mar 6;37(5):765-73.
RGD ID: 633994
Pubmed: PMID:12628167   (View Abstract at PubMed)

Na(+)-activated potassium channels (K(Na)) have been identified in cardiomyocytes and neurons where they may provide protection against ischemia. We now report that K(Na) is encoded by the rSlo2 gene (also called Slack), the mammalian ortholog of slo-2 in C. elegans. rSlo2, heterologously expressed, shares many properties of native K(Na) including activation by intracellular Na(+), high conductance, and prominent subconductance states. In addition to activation by Na(+), we report that rSLO-2 channels are cooperatively activated by intracellular Cl(-), similar to C. elegans SLO-2 channels. Since intracellular Na(+) and Cl(-) both rise in oxygen-deprived cells, coactivation may more effectively trigger the activity of rSLO-2 channels in ischemia. In C. elegans, mutational and physiological analysis revealed that the SLO-2 current is a major component of the delayed rectifier. We demonstrate in C. elegans that slo-2 mutants are hypersensitive to hypoxia, suggesting a conserved role for the slo-2 gene subfamily.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
potassium ion transport  IDA 633994 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
potassium channel activity  IDA 633994 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnt1  (potassium sodium-activated channel subfamily T member 1)


Additional Information