RGD Reference Report - GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. - Rat Genome Database

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GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.

Authors: Luo, HR  Saiardi, A  Nagata, E  Ye, K  Yu, H  Jung, TS  Luo, X  Jain, S  Sawa, A  Snyder, SH 
Citation: Luo HR, etal., Neuron 2001 Aug 16;31(3):439-51.
RGD ID: 632896
Pubmed: PMID:11516400   (View Abstract at PubMed)

Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a novel protein, GRAB (guanine nucleotide exchange factor for Rab3A), which interacts with both InsP6K1 and Rab3A, a Ras-like GTPase that regulates synaptic vesicle exocytosis. GRAB is a physiologic GEF (guanine nucleotide exchange factor) for Rab3A. Consistent with a role of Rab3A in synaptic vesicle exocytosis, GRAB regulates depolarization-induced release of dopamine from PC12 cells and nicotinic agonist-induced hGH release from bovine adrenal chromaffin cells. The association of InsP6K1 with GRAB fits with a role for InsP7 in vesicle exocytosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Ip6k1  (inositol hexakisphosphate kinase 1)
Rab3a  (RAB3A, member RAS oncogene family)
Rab3il1  (RAB3A interacting protein-like 1)


Additional Information