RGD Reference Report - CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. - Rat Genome Database

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CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.

Authors: Niethammer, M  Valtschanoff, JG  Kapoor, TM  Allison, DW  Weinberg, TM  Craig, AM  Sheng, M 
Citation: Niethammer M, etal., Neuron 1998 Apr;20(4):693-707.
RGD ID: 632510
Pubmed: PMID:9581762   (View Abstract at PubMed)

The synaptic protein PSD-95/SAP90 binds to and clusters a variety of membrane proteins via its two N-terminal PDZ domains. We report a novel protein, CRIPT, which is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. While conforming to the consensus PDZ-binding C-terminal sequence (X-S/T-X-V-COOH), residues at the -1 position and upstream of the last four amino acids of CRIPT determine its specificity for PDZ3. In heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colocalizes with PSD-95 in the postsynaptic density and can be coimmunoprecipitated with PSD-95 and tubulin. These findings suggest that CRIPT may regulate PSD-95 interaction with a tubulin-based cytoskeleton in excitatory synapses.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cytoplasmic microtubule organization  IDA 632510 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendrite  IDA 632510 RGD 
dendritic shaft  IDA 632510 RGD 
dendritic spine  IDA 632510 RGD 
neuronal cell body  IDA 632510 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PDZ domain binding  IDA 632510PSD-95RGD 
protein binding  IPICript (Rattus norvegicus)632510 RGD 
protein-containing complex binding  IPIDlgap2 (Rattus norvegicus) more ...632510beta-tubulinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cript  (CXXC repeat containing interactor of PDZ3 domain)
Dlgap2  (DLG associated protein 2)


Additional Information