RGD Reference Report - Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus. - Rat Genome Database

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Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus.

Authors: Skoldberg, F  Ronnblom, L  Thornemo, M  Lindahl, A  Bird, PI  Rorsman, F  Kampe, O  Landgren, E 
Citation: Skoldberg F, etal., Biochem Biophys Res Commun 2002 Mar 8;291(4):951-8.
RGD ID: 625427
Pubmed: PMID:11866458   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2002.6534   (Journal Full-text)

To identify candidate autoantigens associated with arthritis, a rat chondrocyte cDNA library was immunoscreened with serum from a patient with rheumatoid arthritis. One isolated cDNA encoded part of AHNAK, a 700-kDa phosphoprotein with DNA binding properties, that appears to be involved in several signal transduction pathways. Immunoreactivity against an in vitro translated human AHNAK fragment was detected in 4.6% (5/109) of patients with rheumatoid arthritis, 29.5% (18/61) of patients with systemic lupus erythematosus (SLE), and 1.2% (2/172) of blood donors. Anti-AHNAK antibodies reacted with a recombinant human AHNAK fragment and with native AHNAK from C32 cell lysates. In vitro translated AHNAK fragment could be cleaved by granzyme B and caspase-3. Anti-AHNAK positive SLE patients had a higher frequency of homogeneous antinuclear antibody staining patterns and a lower frequency of recent mucosal ulcerations. This is the first report that AHNAK can be targeted by the immune system in autoimmune disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autoimmune disease  IDA 625427 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ahnak  (AHNAK nucleoprotein)


Additional Information