RGD Reference Report - Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF. - Rat Genome Database

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Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.

Authors: Watanabe, TK  Okuno, S  Oga, K  Mizoguchi-Miyakita, A  Tsuji, A  Yamasaki, Y  Hishigaki, H  Kanemoto, N  Takagi, T  Takahashi, E  Irie, Y  Nakamura, Y  Tanigami, A 
Citation: Watanabe TK, etal., Genomics 1999 Jun 15;58(3):233-9.
RGD ID: 619678
Pubmed: PMID:10373320   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.1999.5789   (Journal Full-text)

To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hyperglycemia  QTM 619678; 619678; 619678 RGD 
obesity  IDA 619678; 619678 RGD 
obesity  IAGP 619678; 619678 RGD 
type 2 diabetes mellitus  QTM 619678; 619678; 619678 RGD 
type 2 diabetes mellitus  IAGP 619678; 619678 RGD 

Phenotype Annotations    Click to see Annotation Detail View

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Objects Annotated

QTLs
Bw115  (Body weight QTL 115)
Bw116  (Body weight QTL 116)
Bw117  (Body weight QTL 117)
Bw118  (Body weight QTL 118)
Bw119  (Body weight QTL 119)
Bw121  (Body weight QTL 121)
Niddm16  (Non-insulin dependent diabetes mellitus QTL 16)
Niddm45  (Non-insulin dependent diabetes mellitus QTL 45)
Niddm49  (Non-insulin dependent diabetes mellitus QTL 49)
Niddm50  (Non-insulin dependent diabetes mellitus QTL 50)

Strains
BN  (BN)
OLETF  (Otsuka Long-Evans Tokushima fatty)


Additional Information