Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.

Authors: Watanabe, TK  Okuno, S  Oga, K  Mizoguchi-Miyakita, A  Tsuji, A  Yamasaki, Y  Hishigaki, H  Kanemoto, N  Takagi, T  Takahashi, E  Irie, Y  Nakamura, Y  Tanigami, A 
Citation: Watanabe TK, etal., Genomics 1999 Jun 15;58(3):233-9.
Pubmed: (View Article at PubMed) PMID:10373320
DOI: Full-text: DOI:10.1006/geno.1999.5789

To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat.

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Created: 2002-08-05
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