RGD Reference Report - Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: linkage analysis with wild rats (Rattus norvegicus). - Rat Genome Database

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Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: linkage analysis with wild rats (Rattus norvegicus).

Authors: Kloting, I  Kovacs, P  Van den Brandt, J 
Citation: Kloting I, etal., Biochem Biophys Res Commun 2001 Jun 29;284(5):1126-33.
RGD ID: 619656
Pubmed: PMID:11414700   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5091   (Journal Full-text)

To study polygenetically inherited human diseases like hypertension, inbred rat strains are usually the preferred models. Because many inbred generations under optimized environmental conditions may have led to the survival of "silent" disease genes, we used a cross between one wild rat and genetically hypertensive SHR rats to analyze quantitative trait loci (QTLs) of blood pressure and related traits. The (Wild x SHR)F1 hybrids were transferred into a pathogen-free environment by wet-hysterectomy and were backcrossed onto SHR to generate first backcross hybrids (BC1). Progeny from one F1 female (n = 72) were phenotypically and genetically characterized to map QTLs. Significant, subsignificant, and suggestive evidence was found for more sex-specific than common linkage of blood pressure and most blood-pressure-related traits. Male- and female-specific regions were determined on different chromosomes for blood pressures (Chrs. 2 and 7 vs 5 and 11), body weight (Chrs. 10 vs 18), and blood glucose (Chr. 17 vs 20). A linkage in both males and females was shown for serum triglycerides on chromosomes 6 and 17, respectively, and blood glucose on chromosome 15. For serum total cholesterol, a significant linkage was found on chromosome 14 only in males. Our findings not only indicate the complex character of quantitative traits per se but also show impressively their dependence on sex, age, and strains in cosegregation analysis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arteriosclerosis  IAGP 619656compared to Wild/K strainRGD 
Hypercholesterolemia  IAGP 619656compared to Wild/K strainRGD 
hyperglycemia  IAGP 619656compared to Wild/K strainRGD 
hypertension  IAGP 619656; 619656; 619656; 619656compared to Wild/K strainRGD 
hypertension MODEL: spontaneousIAGP 619656compared to Wild/K strainRGD 
Hypertriglyceridemia  IAGP 619656compared to Wild/K strainRGD 
obesity  IAGP 619656; 619656compared to Wild/K strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased circulating glucose level  IAGP 619656compared to Wild/K strainRGD 
decreased circulating triglyceride level sexual_dimorphismIAGP 619656in males and compared to Wild/K strainRGD 
hypertension  IAGP 619656 RGD 
increased body weight  IAGP 619656; 619656compared to Wild/K strainRGD 
increased circulating cholesterol level sexual_dimorphismIAGP 619656in males and compared to Wild/K strainRGD 
increased circulating cholesterol level  IAGP 619656compared to Wild/K strainRGD 
increased circulating glucose level  IAGP 619656compared to Wild/K strainRGD 
increased circulating triglyceride level  IAGP 619656compared to Wild/K strainRGD 
increased systemic arterial blood pressure  IAGP 619656; 619656; 619656; 619656compared to Wild/K strainRGD 
increased systemic arterial systolic blood pressure  IAGP 619656compared to Wild/K strainRGD 

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Objects Annotated

QTLs
Bp101  (Blood pressure QTL 101)
Bp102  (Blood pressure QTL 102)
Bp103  (Blood pressure QTL 103)
Bp104  (Blood pressure QTL 104)
Bw10  (Body weight QTL 10)
Bw11  (Body weight QTL 11)
Gluco31  (Glucose level QTL 31)
Scl11  (Serum cholesterol level QTL 11)
Stl1  (Serum triglyceride level QTL 1)

Strains
SHR/Mol  (NA)
Wild/K  (NA)


Additional Information