RGD Reference Report - Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat. - Rat Genome Database

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Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat.

Authors: Cai, LQ  Imperato-McGinley, J  Zhu, YS 
Citation: Cai LQ, etal., Prostate. 2006 May 15;66(7):738-48.
RGD ID: 4891920
Pubmed: PMID:16425201   (View Abstract at PubMed)
DOI: DOI:10.1002/pros.20397   (Journal Full-text)

BACKGROUND: High-fat diet is a major risk factor for prostate cancer. 5alpha-reductases are potential targets of dietary fat. METHODS: Male ACI/Seg rats given either a low-fat or a high-fat diet at weaning or adulthood were sacrificed at 2, 4, and 10 weeks after dietary treatment. Prostate 5alpha-reductase mRNAs, plasma androgens, food consumption, prostate, and body weight were determined. RESULTS: Prostate 5alpha-reductase-2 mRNA and plasma dihydrotestosterone levels were elevated at 2 weeks, and prostate weight was increased at 10 weeks in neonatal rats fed the high-fat diet. Animals fed the high-fat diet consumed more calories in the first 4 weeks. 5alpha-reductase-1 mRNA, plasma testosterone, and body weight were not different between the two dietary groups. These dietary effects were not observed in adult rats fed the same diets. CONCLUSION: A high-dietary fat and caloric intake upregulates prostate 5alpha-reductase-2 gene expression, and stimulates prostate growth in neonatal, but not adult rats.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient levels  IEP 4891920high-fat dietRGD 

Objects Annotated

Genes (Rattus norvegicus)
Srd5a2  (steroid 5 alpha-reductase 2)


Additional Information