RGD Reference Report - A role for MCP-1/CCR2 in interstitial lung disease in children. - Rat Genome Database

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A role for MCP-1/CCR2 in interstitial lung disease in children.

Authors: Hartl, D  Griese, M  Nicolai, T  Zissel, G  Prell, C  Reinhardt, D  Schendel, DJ  Krauss-Etschmann, S 
Citation: Hartl D, etal., Respir Res. 2005 Aug 11;6:93.
RGD ID: 4145064
Pubmed: PMID:16095529   (View Abstract at PubMed)
PMCID: PMC1199626   (View Article at PubMed Central)
DOI: DOI:10.1186/1465-9921-6-93   (Journal Full-text)

BACKGROUND: Interstitial lung diseases (ILD) are chronic inflammatory disorders leading to pulmonary fibrosis. Monocyte chemotactic protein 1 (MCP-1) promotes collagen synthesis and deletion of the MCP-1 receptor CCR2 protects from pulmonary fibrosis in ILD mouse models. We hypothesized that pulmonary MCP-1 and CCR2+ T cells accumulate in pediatric ILD and are related to disease severity. METHODS: Bronchoalveolar lavage fluid was obtained from 25 children with ILD and 10 healthy children. Levels of pulmonary MCP-1 and Th1/Th2-associated cytokines were quantified at the protein and the mRNA levels. Pulmonary CCR2+, CCR4+, CCR3+, CCR5+ and CXCR3+ T cells were quantified by flow-cytometry. RESULTS: CCR2+ T cells and MCP-1 levels were significantly elevated in children with ILD and correlated with forced vital capacity, total lung capacity and ILD disease severity scores. Children with lung fibrosis had significantly higher MCP-1 levels and CCR2+ T cells in bronchoalveolar lavage fluid compared to non-fibrotic children. CONCLUSION: The results indicate that pulmonary CCR2+ T cells and MCP-1 contribute to the pathogenesis of pediatric ILD and might provide a novel target for therapeutic strategies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
interstitial lung disease severityIEP 4145064protein:increased expression: T cellRGD 
interstitial lung disease severityISOCCR2 (Homo sapiens)4145064; 4145064protein:increased expression: T cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Mus musculus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Homo sapiens)
CCR2  (C-C motif chemokine receptor 2)


Additional Information