RGD Reference Report - Reversal of sulfamerazine inhibition of rat hepatic uroporphyrinogen synthesis by folic acid. - Rat Genome Database

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Reversal of sulfamerazine inhibition of rat hepatic uroporphyrinogen synthesis by folic acid.

Authors: Christenson, WR  Reddy, VR  Piper, WN 
Citation: Christenson WR, etal., Life Sci. 1986 May 5;38(18):1679-84.
RGD ID: 4144820
Pubmed: PMID:3702597   (View Abstract at PubMed)

The ability of rat hepatic uroporphyrinogen cosynthase to direct formation of uroporphyrinogen III and the synthesis of uroporphyrinogen in vitro was impaired by sulfamerazine. Inhibition was reversed by the addition of folic acid. Administration of a single, oral dose (1 g/kg) of sulfamerazine to rats was associated with elevated levels of hepatic uroporphyrin I isomer. These results suggest that sulfonamides may interfere with the biosynthesis of uroporphyrinogen III.

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sulfamerazine increases activityISOHmbs (Rattus norvegicus)4144820; 4144820Sulfamerazine increases activity of purified Hmbs proteinRGD 
sulfamerazine increases activityEXP 4144820Sulfamerazine increases activity of purified Hmbs proteinRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
porphyrin-containing compound biosynthetic process  IDA 4144820UroporphyrinogenRGD 
porphyrin-containing compound metabolic process  IDA 4144820Porphobilinogen RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hydroxymethylbilane synthase activity  IDA 4144820 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmbs  (hydroxymethylbilane synthase)

Genes (Mus musculus)
Hmbs  (hydroxymethylbilane synthase)

Genes (Homo sapiens)
HMBS  (hydroxymethylbilane synthase)


Additional Information