RGD Reference Report - Effects of lead on the heme biosynthetic pathway in rat kidney. - Rat Genome Database

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Effects of lead on the heme biosynthetic pathway in rat kidney.

Authors: Oskarsson, A  Fowler, BA 
Citation: Oskarsson A and Fowler BA, Exp Mol Pathol. 1985 Dec;43(3):409-17.
RGD ID: 4144206
Pubmed: PMID:4065316   (View Abstract at PubMed)

Exposure of rats to lead in drinking water at concentrations of 500 ppm and 1000 ppm for 3 and 6 months resulted in elevated blood lead levels, formation of kidney intranuclear inclusion bodies, and increased urinary excretion of uroporphyrin and coproporphyrin. The erythrocytic Zn-protoporphyrin was increased in the highest dose group. No significant effects on body weight gain or kidney weight were observed. Renal activity of delta-aminolevulinic acid synthetase (ALAS) was not significantly affected by lead treatment. The renal activity of delta-aminolevulinic acid dehydrase (ALAD) was moderately increased and ferrochelatase activity was significantly decreased. The relatively small effects of chronic lead exposure on renal heme biosynthesis suggests that intracellular complexation of lead with high-affinity renal lead binding proteins (PbBP) and formation of intranuclear inclusions in proximal tubule cells protects this highly sensitive pathway in kidney from lead inhibition in vivo. These data also suggest that the observed increases in urinary porphyrin excretion are primarily due to lead effects on the erythropoietic system.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to lead ion  IEP 4144206 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fech  (ferrochelatase)


Additional Information