RGD Reference Report - Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats. - Rat Genome Database

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Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats.

Authors: Yamazaki, Y  Kanno, H  Maeda, K  Yoshida, T  Kobayashi, N  Kubo, A  Yamaguchi, Y  Saito, T 
Citation: Yamazaki Y, etal., Neuroreport. 2010 Mar 10;21(4):287-92.
RGD ID: 2325181
Pubmed: PMID:20125055   (View Abstract at PubMed)
DOI: DOI:10.1097/WNR.0b013e328336ee9a   (Journal Full-text)

Stem cell-based therapy using bone marrow stromal cells (MSCs) has been expected to be a promising therapy for neuronal regeneration. To repair the injured spinal cord, neuronal differentiation of MSCs before transplantation has a more satisfactory effect. Recently, neuronal differentiation of neural progenitor/stem cells by an intracellular delivery of a pVHL-derived synthetic peptide (VHL peptide) has been shown. Here, we show that VHL peptide-delivered MSCs differentiated into neuron-like cells, and that engrafted VHL peptide-delivered MSCs more recovered the behaviors of the rats than that of nondelivered MSCs. Our result suggests that the use of VHL peptide-delivered MSCs would be a promising therapeutic strategy for repairing the injured spinal cord.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Cord Injuries  ISOVhl (Rattus norvegicus)2325181; 2325181 RGD 
Spinal Cord Injuries  IDA 2325181 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron differentiation  IDA 2325181 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vhl  (von Hippel-Lindau tumor suppressor)

Genes (Mus musculus)
Vhl  (von Hippel-Lindau tumor suppressor)

Genes (Homo sapiens)
VHL  (von Hippel-Lindau tumor suppressor)


Additional Information