RGD Reference Report - Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomerulosclerosis. - Rat Genome Database

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Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomerulosclerosis.

Authors: Sato, T  Liang, K  Vaziri, ND 
Citation: Sato T, etal., Kidney Int. 2002 Jan;61(1):157-62.
RGD ID: 2324671
Pubmed: PMID:11786096   (View Abstract at PubMed)
DOI: DOI:10.1046/j.1523-1755.2002.00104.x   (Journal Full-text)

BACKGROUND: Patients and animals with nephrotic syndrome and those with chronic renal failure (CRF) often exhibit hypertriglyceridemia and impaired very low-density lipoprotein (VLDL) clearance. Imai rats that were originally derived from Sprague-Dawley rats develop spontaneous proteinuria, hyperlipidemia, progressive renal insufficiency and histologic changes of focal glomerulosclerosis (FGS), closely resembling human FGS. This study was undertaken to test the hypothesis that elevation of plasma triglyceride and VLDL concentrations in the Imai rats is associated with deficiency of lipoprotein lipase (LPL) and VLDL receptor which are the main pathways of triglyceride-rich lipoprotein clearance. METHODS: Male Imai and Sprague-Dawley control rats were fed regular rat chow and studied at 10 and 34 weeks of age. Tissue LPL and VLDL-r protein abundance (Western analysis) and post-heparin lipolytic activity were determined. RESULTS: At 10 weeks of age, Imai rats showed mild proteinuria, moderate hyperlipidemia, normal creatinine clearance and blood pressure. By 34 weeks of age, the study animal exhibited severe proteinuria, marked hyperlipidemia, significant renal insufficiency and hypertension. This was associated with a severe progressive reduction in skeletal muscle and adipose tissue LPL and VLDL-r protein abundance and depressed plasma post heparin, lipolytic activity. CONCLUSION: Progressive hyperlipidemia in the Imai rats with spontaneous FGS is accompanied by severe combined LPL and VLDL-r deficiencies that can, in part, account for the associated hypertriglyceridemia and elevated plasma VLDL concentrations.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
focal segmental glomerulosclerosis  ISOVldlr (Rattus norvegicus)2324671; 2324671protein:decreased expression:adipose tissue and skeletal muscle (rat)RGD 
focal segmental glomerulosclerosis  IEP 2324671protein:decreased expression:adipose tissue and skeletal muscle (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vldlr  (very low density lipoprotein receptor)

Genes (Mus musculus)
Vldlr  (very low density lipoprotein receptor)

Genes (Homo sapiens)
VLDLR  (very low density lipoprotein receptor)


Additional Information