RGD Reference Report - Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). - Rat Genome Database

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Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN).

Authors: Karamitopoulou, E  Zlobec, I  Tornillo, L  Carafa, V  Schaffner, T  Brunner, T  Borner, M  Diamantis, I  Zimmermann, A  Terracciano, L 
Citation: Karamitopoulou E, etal., Pathology. 2010 Apr;42(3):229-34.
RGD ID: 2317703
Pubmed: PMID:20350215   (View Abstract at PubMed)
DOI: DOI:10.3109/00313021003631379   (Journal Full-text)

AIMS: Pancreatic cancer is an aggressive tumour following a multistep progression model through precursors called pancreatic intraepithelial neoplasia (PanIN). Identification of reliable prognostic markers would help in improving survival. The aim of this study was to investigate the role as well as the prognostic significance of different cell cycle and proliferation markers, namely p21, p27, p53 and Ki-67, in pancreatic carcinogenesis. METHODS: We analysed the expression of p21, p27, p53 and Ki-67, in 210 ductal pancreatic adenocarcinomas, 40 PanIN-3 cases and 40 normal controls combined in a tissue microarray. The results were correlated with clinicopathological and follow-up data. RESULTS: Our study revealed a differential p27, p21, p53, and Ki-67 expression between ductal adenocarcinoma, PanIN-3 and normal pancreas. p27 expression progressively decreased from normal pancreas to PanIN and to pancreatic cancer. Decreased p27 and increased p53 expression showed a significant association with the T stage. A Ki-67 >5% correlated with reduced survival. CONCLUSIONS: In pancreatic cancer, loss of p27 and increased p53 expression is associated with a more aggressive phenotype. p27 may play an important role in pancreatic carcinogenesis. A Ki-67 >5% independently predicted poor outcome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
in situ carcinoma  IEP 2317703associated with Pancreatic Neoplasms and protein:increased expression:pancreasRGD 
in situ carcinoma  ISOMKI67 (Homo sapiens)2317703; 2317703associated with Pancreatic Neoplasms and protein:increased expression:pancreasRGD 
pancreatic cancer disease_progressionIEP 2317703protein:increased expression:pancreasRGD 
pancreatic cancer disease_progressionISOMKI67 (Homo sapiens)2317703; 2317703protein:increased expression:pancreasRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mki67  (marker of proliferation Ki-67)

Genes (Mus musculus)
Mki67  (antigen identified by monoclonal antibody Ki 67)

Genes (Homo sapiens)
MKI67  (marker of proliferation Ki-67)


Additional Information