RGD Reference Report - L-Asparagine synthetase in serum as a marker for neoplasia. - Rat Genome Database

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L-Asparagine synthetase in serum as a marker for neoplasia.

Authors: Cooney, DA  King, VD  Cable, RG  Taylor B, JR  Wodinsky, I 
Citation: Cooney DA, etal., Cancer Res. 1976 Sep;36(9 pt.1):3238-45.
RGD ID: 2316006
Pubmed: PMID:10081   (View Abstract at PubMed)

L-Asparagine synthetase appears in serum approximately 7 days after the s.c. implantation of 1 X 10(5) cells of Leukemia 5178Y/AR (resistant to L-asparaginase) and increases in activity as the neoplasm grows and metastasizes. The principal source of the enzyme is the primary tumor. After intravranial inoculation of tumor, the rate of leakage of the enzyme is more pronounced than when the subcutaneous, intramuscular, or intraperitoneal routes are used. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037), a nitro-sourea effective in the palliation of L5178Y/AR, temporarily halts the influx of enzyme into the blood stream, as does surgical excision of the s.c. tumor nodules. Treatment of mice with L-asparaginase within 24 hr of inoculation of the tumor markedly augments both tumor growth and the rate of penetration of L-asparagine synthetase into the circulation. Several other L-asparagine synthetase into the circulation. Several other L-asparaginase-resistant tumors also were found to spill L-asparagine synthetase into the serum, but the correlation between this phenomenon and the specific activity of the enzyme in homogenates of the tumor was imperfect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma  ISOAsns (Rattus norvegicus)2316006; 2316006protein:increased activity:serum (rat)RGD 
hepatocellular carcinoma  IEP 2316006protein:increased activity:serum (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Asns  (asparagine synthetase (glutamine-hydrolyzing))

Genes (Mus musculus)
Asns  (asparagine synthetase)

Genes (Homo sapiens)
ASNS  (asparagine synthetase (glutamine-hydrolyzing))


Additional Information