RGD Reference Report - Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats. - Rat Genome Database

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Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats.

Authors: Laing, CJ  Fraser, DR 
Citation: Laing CJ and Fraser DR, Br J Nutr. 2002 Aug;88(2):133-9.
RGD ID: 2315500
Pubmed: PMID:12144717   (View Abstract at PubMed)
DOI: DOI:10.1079/BJNBJN2002611   (Journal Full-text)

The work presented here examines the possible effects of nutritional deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat. Deficiencies in both dietary protein intake and dietary energy intake may decrease the concentration of DBP in the circulation, although plasma DBP was not affected by dietary Ca deficiency. None of the dietary factors examined appears to influence the affinity of DBP for its major ligand, 25-hydroxycholecalciferol (25(OH)D(3)). Protein-deficient rats seemed to have difficulty in maintaining adequate concentrations of 1,25-dihydroxycholecalciferol (1,25(OH)(2)D(3)) in the circulation. The sensitivity of DBP to dietary protein and energy intake may constitute a novel mechanism that may help to explain the observed associations between malnutrition and the development of metabolic bone disease, through alterations to the cellular availability of vitamin D ligands to DBP.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient levels  IEP 2315500 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gc  (GC, vitamin D binding protein)


Additional Information