RGD Reference Report - Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration. - Rat Genome Database

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Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration.

Authors: McClain, JA  Phillips, LL  Fillmore, HL 
Citation: McClain JA, etal., Neurosci Lett. 2009 Aug 21;460(1):27-31. Epub 2009 May 20.
RGD ID: 2314505
Pubmed: PMID:19463894   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2009.05.044   (Journal Full-text)

Accumulating evidence indicates that neuroinflammation contributes significantly to progressive dopaminergic (DA) neurodegeneration in Parkinson's disease (PD). Altered matrix metalloproteinase-3 (MMP-3) expression has been reported in several neuroinflammatory paradigms; however, its relationship to inflammation-induced DA neurotoxicity has not been explored. To this end, we investigated the temporal expression pattern of MMP-3 and one of its downstream targets, connective tissue growth factor (CTGF), following lipopolysaccharide (LPS)-induced DA neurodegeneration. LPS was directly injected into the substantia nigra of male Sprague-Dawley rats. Lesion formation was confirmed with immunohistochemistry 48 h post-injection. MMP-3 and CTGF were measured by western blot 12, 24, and 48 h post-injection. In association with neurodegeneration, MMP-3 expression and activation was significantly increased 24 and 48 h after LPS injection. In addition, CTGF expression increased 5-fold at the 24h time point. The temporal changes in MMP-3 and CTGF expression corresponded to the neurodegenerative phase of this model, suggesting that these two proteins may participate in neuroinflammation-induced DA neurotoxicity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease  ISOCcn2 (Rattus norvegicus)2314505; 2314505protein:increased expression:substantia nigra (rat)RGD 
Parkinson's disease  IEP 2314505protein:increased expression:substantia nigra (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccn2  (cellular communication network factor 2)

Genes (Mus musculus)
Ccn2  (cellular communication network factor 2)

Genes (Homo sapiens)
CCN2  (cellular communication network factor 2)


Additional Information