RGD Reference Report - Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population. - Rat Genome Database

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Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population.

Authors: Daimon, M  Ji, G  Saitoh, T  Oizumi, T  Tominaga, M  Nakamura, T  Ishii, K  Matsuura, T  Inageda, K  Matsumine, H  Kido, T  Htay, L  Kamatani, N  Muramatsu, M  Kato, T 
Citation: Daimon M, etal., Biochem Biophys Res Commun. 2003 Mar 21;302(4):751-8.
RGD ID: 2313434
Pubmed: PMID:12646233   (View Abstract at PubMed)

The etiology of type 2 diabetes (DM) is polygenic. We investigated here genes and polymorphisms that associate with DM in the Japanese population. Single-nucleotide polymorphisms (SNPs) of 398 derived from 120 candidate genes were examined for association with DM in a population-based case-control study. The study group consisted of 148 cases and 227 controls recruited from Funagata, Japan. No evident subpopulation structure was detected for the tested population. The association tests were conducted with standard allele positivity tables (chi(2) tests) between SNP genotype frequency and case-control status. The independent association of the SNPs from serum triglyceride levels and body mass index was examined by multiple logistic regression analysis. A value of P<0.01 was accepted as statistically significant. Six genes (met proto-oncogene, ATP-binding cassette transporter A1, fatty acid binding protein 2, LDL receptor defect C complementing, aldolase B, and sulfonylurea receptor) were shown to be associated with DM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IAGP 2313434DNA:SNP:intron: (human)RGD 
type 2 diabetes mellitus  ISOALDOB (Homo sapiens)2313434; 2313434DNA:SNP:intron: (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aldob  (aldolase, fructose-bisphosphate B)

Genes (Mus musculus)
Aldob  (aldolase B, fructose-bisphosphate)

Genes (Homo sapiens)
ALDOB  (aldolase, fructose-bisphosphate B)


Additional Information