RGD Reference Report - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - Rat Genome Database

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Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Authors: Wu, XJ  Qin, L  Zhou, JY  Cheng, JL  Shen, MY  Wang, JS  Zhou, L 
Citation: Wu XJ, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Dec;24(6):656-9.
RGD ID: 2306799
Pubmed: PMID:18067077   (View Abstract at PubMed)

OBJECTIVE: To investigate the association between a polymorphism (rs228648) of urotensin II (UT-II) gene and type 2 diabetes in pedigrees. METHODS: Patients and controls with/without familial history were enrolled in the same place. RESULTS: Carriers with AG or AA genotype from pedigrees had higher disease risk than those with GG genotype (OR=1.98, 95% CI:1.19-3.29,OR=2.46,95% CI:1.39-4.34), the frequency of A allele was higher in the patients from pedigrees than inner controls and patients who had no familial history (P=0.01). The frequency of A allele was higher in the inner controls than outer ones (P=0.001). The insulin resistance index, insulin sensitivity index and pancreatic secretion index of inner controls with AG genotype were higher than those with GG genotype (All P < 0.05). CONCLUSION: This polymorphism of UT-II gene might be a risk to type 2 diabetes, the insulin function of people from pedigrees is associated with the mutation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IAGP 2306799DNA:polymorphismRGD 
type 2 diabetes mellitus  ISOUTS2 (Homo sapiens)2306799; 2306799DNA:polymorphismRGD 

Objects Annotated

Genes (Rattus norvegicus)
Uts2  (urotensin 2)

Genes (Mus musculus)
Uts2  (urotensin 2)

Genes (Homo sapiens)
UTS2  (urotensin 2)


Additional Information