RGD Reference Report - Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.

Authors: Asahina, M  Haruyama, W  Ichida, Y  Sakamoto, M  Sato, M  Imaizumi, K 
Citation: Asahina M, etal., J Lipid Res. 2008 Aug 27.
RGD ID: 2300117
Pubmed: PMID:18753676   (View Abstract at PubMed)
DOI: DOI:10.1194/jlr.M800135-JLR200   (Journal Full-text)

We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation crossed of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed interval-specific congenic lines (ISCLs) and carried out expression and sequencing analyses. Here we narrowed Dihc2 to region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypercholesterolemia inducedIAGPcontrolled cholesterol content diet and controlled fat content diet2300117 RGD 
Hypercholesterolemia  IAGP 2300117 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Scl59  (Serum cholesterol level QTL 59)

Objects referenced in this article
Gene PPP4R3B protein phosphatase 4 regulatory subunit 3B Homo sapiens
Gene Ppp4r3b protein phosphatase 4 regulatory subunit 3B Mus musculus
Marker D14Kyu7 D14Kyu7 Rattus norvegicus
Marker D14Kyu8 D14Kyu8 Rattus norvegicus
Strain BN/Seac null Rattus norvegicus
Gene Ppp4r3b protein phosphatase 4, regulatory subunit 3B Rattus norvegicus
QTL Scl45 Serum cholesterol level QTL 45 Rattus norvegicus

Additional Information