Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats.

Authors: Pendergrass, KD  Pirro, NT  Westwood, BM  Ferrario, CM  Brosnihan, KB  Chappell, MC 
Citation: Pendergrass KD, etal., Am J Physiol Heart Circ Physiol. 2008 May 2;.
Pubmed: (View Article at PubMed) PMID:18456730
DOI: Full-text: DOI:10.1152/ajpheart.01277.2007

Sex differences in blood pressure are evident in experimental models and human subjects, yet the mechanisms underlying this disparity remain equivocal. The current study sought to define the extent of male-female differences in the circulating and tissue renin-angiotensin aldosterone systems (RAAS) of the congenic mRen2.Lewis and the control Lewis rats. Male congenics exhibited higher systolic blood pressure than females [200 +/- 4 vs. 146 +/- 7 mmHg, p 0.05]. Plasma Ang II levels were 2-fold higher in male congenics [47 +/- 3 vs. 19 +/- 3 pM, p

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RGD Object Information
RGD ID: 2293121
Created: 2008-05-13
Species: All Species
Last Modified: 2008-05-13
Status: ACTIVE



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