RGD Reference Report - Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats. - Rat Genome Database

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Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats.

Authors: Pendergrass, KD  Pirro, NT  Westwood, BM  Ferrario, CM  Brosnihan, KB  Chappell, MC 
Citation: Pendergrass KD, etal., Am J Physiol Heart Circ Physiol. 2008 May 2;.
RGD ID: 2293121
Pubmed: PMID:18456730   (View Abstract at PubMed)
PMCID: PMC2494740   (View Article at PubMed Central)
DOI: DOI:10.1152/ajpheart.01277.2007   (Journal Full-text)

Sex differences in blood pressure are evident in experimental models and human subjects, yet the mechanisms underlying this disparity remain equivocal. The current study sought to define the extent of male-female differences in the circulating and tissue renin-angiotensin aldosterone systems (RAAS) of the congenic mRen2.Lewis and the control Lewis rats. Male congenics exhibited higher systolic blood pressure than females [200 +/- 4 vs. 146 +/- 7 mmHg, p 0.05]. Plasma Ang II levels were 2-fold higher in male congenics [47 +/- 3 vs. 19 +/- 3 pM, p

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
proteinuria  IMP 2293121 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal circulating C-reactive protein level  IMP 2293121compared to LEW/CrlRGD 
abnormal circulating C-reactive protein level sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/JmulRGD 
abnormal circulating C-reactive protein level sexual_dimorphismIAGP 2293121compared to female LEW/CrlRGD 
decreased body weight sexual_dimorphismIAGP 2293121compared to female LEW-TgRen227/JmulRGD 
decreased circulating angiotensinogen level sexual_dimorphismIMP 2293121compared to female LEW/CrlRGD 
decreased heart left ventricle weight sexual_dimorphismIAGP 2293121compared to female LEW/CrlRGD 
decreased kidney weight sexual_dimorphismIMP 2293121compared to female LEW/CrlRGD 
decreased kidney weight sexual_dimorphismIAGP 2293121compared to female LEW/CrlRGD 
decreased renin activity sexual_dimorphismIMP 2293121compared to female LEW/CrlRGD 
decreased renin activity sexual_dimorphismIAGP 2293121compared to female LEW/Crl in kidneyRGD 
increased angiotensin I-converting enzyme activity  IMP 2293121compared to male LEW/Crl and plasma and corticalRGD 
increased angiotensin I-converting enzyme activity sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/Jmul and plasma and corticalRGD 
increased body weight sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/JmulRGD 
increased body weight sexual_dimorphismIAGP 2293121compared to female LEW/CrlRGD 
increased circulating renin level  IMP 2293121compared to LEW/Crl��RGD 
increased circulating renin level sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/JmulRGD 
increased heart left ventricle weight sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/JmulRGD 
increased kidney weight sexual_dimorphismIMP 2293121compared to male LEW/Crl and compared to female LEW-TgRen227/JmulRGD 
increased systemic arterial systolic blood pressure  IMP 2293121compared to LEW/Crl�RGD 
increased systemic arterial systolic blood pressure sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/JmulRGD 
increased urine creatinine level  IMP 2293121 RGD 
increased urine creatinine level sexual_dimorphismIMP 2293121compared to female LEW-TgRen227/JmulRGD 
increased urine protein level sexual_dimorphismIMP 2293121compared to male LEW/Crl and compared to female LEW-TgRen227/JmulRGD 
Objects Annotated

Strains
LEW-Tg(Ren2)27/Jmul  (NA)
LEW/Crl  (Lewis)


Additional Information