RGD Reference Report - Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. - Rat Genome Database

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Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases.

Authors: Esposito, NN  Mohan, D  Brufsky, A  Lin, Y  Kapali, M  Dabbs, DJ 
Citation: Esposito NN, etal., Arch Pathol Lab Med. 2006 Oct;130(10):1516-21.
RGD ID: 2289654
Pubmed: PMID:17090194   (View Abstract at PubMed)
DOI: DOI:10.1043/1543-2165(2006)130[1516:PTACAI]2.0.CO;2   (Journal Full-text)

CONTEXT: Phyllodes tumors (PTs) of the breast are biphasic neoplasms composed of epithelium and a spindle-cell stroma. Currently, PTs are classified as benign, borderline, or malignant based on histopathologic features. However, histologic classification does not always predict outcome. Objective.-To determine the prognostic value of a variety of clinicopathologic features and immunoreactivities in PTs. DESIGN: Sixteen benign, 8 borderline, and 6 malignant PTs with follow-up were examined for reactivity across a panel of immunohistochemical stains, including c-Kit, endothelin 1, p16, p21, p53, and Ki-67. Clinicopathologic features, including stromal cellularity, mitotic rate, and margin status, were also assessed. Tumor variables were compared among tumor subgroups and between tumors that did and did not recur. RESULTS: Of the 30 PTs, 4 recurred (1 benign, 2 borderline, 1 malignant). One patient with a malignant tumor died of metastatic disease 34 months after initial diagnosis. The overall positive rate of c-Kit immunoreactivity was 13% in benign, 63% in borderline, and 67% in malignant PTs. Endothelin 1 epithelial cytoplasmic staining was seen in 100% of benign, 50% of borderline, and 17% of malignant PTs. Additionally, p16, p21, p53, and Ki-67 were differentially expressed among benign, borderline, and malignant tumors. Positive surgical resection margins was the only variable that significantly predicted recurrent disease (P = .02). CONCLUSIONS: Stromal c-Kit positivity and epithelial endothelin 1 negativity are more often associated with malignant PTs; however, only positive margin status is significantly associated with tumor behavior.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Phyllodes Tumor severityIEP 2289654 RGD 
Phyllodes Tumor severityISOCDKN1A (Homo sapiens)2289654; 2289654 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1a  (cyclin-dependent kinase inhibitor 1A)

Genes (Mus musculus)
Cdkn1a  (cyclin dependent kinase inhibitor 1A)

Genes (Homo sapiens)
CDKN1A  (cyclin dependent kinase inhibitor 1A)


Additional Information